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环状 RNA circ_0006423 对非小细胞肺癌的诊断价值及其作为 miRNA-492 海绵的抑癌基因作用

The diagnostic value of has_circ_0006423 in non-small cell lung cancer and its role as a tumor suppressor gene that sponges miR-492.

机构信息

Department of Cardiothoracic Surgery, Ningbo Medical Center Lihuili Hospital, 57 Xingning Road, Yinzhou District, Ningbo City, 315040, Zhejiang, China.

Department of Cardiothoracic Surgery, Lihuili Hospital Affiliated to Ningbo University, Ningbo City, Zhejiang, China.

出版信息

Sci Rep. 2022 Aug 12;12(1):13722. doi: 10.1038/s41598-022-17816-6.

DOI:10.1038/s41598-022-17816-6
PMID:35962012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9374755/
Abstract

The diagnosis and treatment of non-small cell lung cancer (NSCLC) are not ideal. We identified NSCLC-related has_circ_0006423 in database. qRT-PCR was used to measure expression levels of hsa_circ_0006423 and miR-492 in the plasma and tissue samples, and 3 NSCLC cell lines, respectively. We analyzed the relationship between expression levels of hsa_circ_0006423 and clinicopathological factors and miR-492 expression in plasma and tissue samples. Assess the diagnostic value of hsa_circ_0006423 and miR-492 in NSCLC. Cell function vitro experiment to explore the effect of has_circ_0006423 on NSCLC. We found has_circ_0006423 is lower expressed in NSCLC and miR-492 is opposite, has_circ_0006423 and miR-492 has diagnostic value in NSCLC. In A549 and NCI-H1299 cells, hsa_circ_0006423 inhibited the proliferation, migration, and invasion of NSCLC cells by sponging miR-492 and accelerating NSCLC cell apoptosis. This effect may be due to the combination of has_circ_0006423 and miR-492 affecting the progression of NSCLC.

摘要

非小细胞肺癌 (NSCLC) 的诊断和治疗并不理想。我们在数据库中鉴定出与 NSCLC 相关的 hsa_circ_0006423。分别使用 qRT-PCR 测量血浆和组织样本中 hsa_circ_0006423 和 miR-492 的表达水平，以及 3 种 NSCLC 细胞系。我们分析了 hsa_circ_0006423 在血浆和组织样本中的表达水平与临床病理因素和 miR-492 表达之间的关系。评估 hsa_circ_0006423 和 miR-492 在 NSCLC 中的诊断价值。体外细胞功能实验探讨了 hsa_circ_0006423 对 NSCLC 的影响。我们发现 hsa_circ_0006423 在 NSCLC 中表达降低，而 miR-492 则相反，hsa_circ_0006423 和 miR-492 在 NSCLC 中具有诊断价值。在 A549 和 NCI-H1299 细胞中，hsa_circ_0006423 通过海绵吸附 miR-492 抑制 NSCLC 细胞的增殖、迁移和侵袭，并加速 NSCLC 细胞凋亡。这种作用可能是由于 hsa_circ_0006423 和 miR-492 的结合影响了 NSCLC 的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/68c55174242d/41598_2022_17816_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/99088f5e9632/41598_2022_17816_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/df582506e009/41598_2022_17816_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/4c53c95794dc/41598_2022_17816_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/1afd6f332787/41598_2022_17816_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/b3dfbbc92ee9/41598_2022_17816_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/523e5a156ba3/41598_2022_17816_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/68c55174242d/41598_2022_17816_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/99088f5e9632/41598_2022_17816_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/629398b0064b/41598_2022_17816_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/df582506e009/41598_2022_17816_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/4c53c95794dc/41598_2022_17816_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/1afd6f332787/41598_2022_17816_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/b3dfbbc92ee9/41598_2022_17816_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/523e5a156ba3/41598_2022_17816_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae8/9374755/68c55174242d/41598_2022_17816_Fig8_HTML.jpg

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