Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Genomics. 2021 Jan;113(1 Pt 2):1233-1246. doi: 10.1016/j.ygeno.2020.10.024. Epub 2020 Oct 22.
Cardiovascular disease (CVD) is an important cause of disease-related death worldwide. One of its main pathological bases is imbalances in gene expression. Non-coding RNAs are a class of transcripts that do not encode proteins. They include microRNA (miRNA), long noncoding RNA (lncRNA) and circular RNA (circRNA). They have important biological functions such as regulating transcription and translation, as well as interacting with DNA, RNA, and proteins. They are also closely associated with pathological processes in CVD. This review will focus on the expression and function of miRNA, lncRNA, circRNA, as well as on their roles and molecular mechanisms in CVDs such as cardiac hypertrophy, heart failure, arrhythmia, myocardial infarction, atherosclerosis, rheumatic heart disease, myocardial fibrosis, pulmonary arterial hypertension. This review will outline concepts provide bases for early diagnosis and targeted treatment of CVDs.
心血管疾病（CVD）是全球疾病相关死亡的重要原因。其主要病理学基础之一是基因表达失衡。非编码 RNA 是一类不编码蛋白质的转录本。它们包括 microRNA（miRNA）、长链非编码 RNA（lncRNA）和环状 RNA（circRNA）。它们具有调节转录和翻译以及与 DNA、RNA 和蛋白质相互作用等重要的生物学功能。它们也与 CVD 的病理过程密切相关。本综述将重点介绍 miRNA、lncRNA 和 circRNA 的表达和功能，以及它们在心脏肥大、心力衰竭、心律失常、心肌梗死、动脉粥样硬化、风湿性心脏病、心肌纤维化、肺动脉高压等 CVD 中的作用和分子机制。本综述将概述概念，为 CVD 的早期诊断和靶向治疗提供基础。
