[哺乳动物中Alu重复序列的进化的各个方面]

[Various aspects of evolution of Alu repeats in mammals].

作者信息

Kolchanov N A, Shakhmuradov I A, Kapitonov V V, Omel'ianchuk L V

出版信息

Mol Biol (Mosk). 1988 Sep-Oct;22(5):1335-44.

Abstract

A complex study on various evolutionary peculiarities of the mammalia dispersed Alu repeats (Alu repeats of primates and B1 of rodents) has been carried out by phylogenetic analysis. A phylogenetic tree, containing the 7SL RNA genes and the Alu repeats of primates and rodents has been constructed. It has been shown that the branch of the phyletic line leading to the Alu repeats of primates and B1 of rodents from the 7SL RNA genes occurred after the divergence of the 7SL RNA genes of amphibia and mammalia, but before the divergence of the 7SL RNA genes of primates and rodents (250.10 years ago). A statistically reliable slowing down in the evolutionary rates of one of two monomers for the human Alu repeats has been proved. It may be caused by the functional load of the corresponding monomer in connection with the presence of a definit regulatory site in it.

摘要

通过系统发育分析，对哺乳动物中分散的Alu重复序列（灵长类动物的Alu重复序列和啮齿动物的B1）的各种进化特性进行了一项复杂的研究。构建了一棵包含7SL RNA基因以及灵长类动物和啮齿动物的Alu重复序列的系统发育树。结果表明，从7SL RNA基因通向灵长类动物的Alu重复序列和啮齿动物的B1的进化谱系分支发生在两栖动物和哺乳动物的7SL RNA基因分歧之后，但在灵长类动物和啮齿动物的7SL RNA基因分歧之前（250.10年前）。已证明人类Alu重复序列的两个单体之一的进化速率在统计学上有可靠的减缓。这可能是由相应单体的功能负荷与其内部存在特定调控位点有关。