Queensland Children's Hospital, Queensland, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.
J Clin Sleep Med. 2022 Dec 1;18(12):2813-2817. doi: 10.5664/jcsm.10228.
To describe the outcomes of central sleep apnea requiring home supplemental oxygen therapy in otherwise healthy term infants.
All children < 1 year of age undergoing polysomnography between 2015 and 2020 at the Queensland Children's Hospital were retrospectively studied. Children with gestational age < 37 weeks, underlying syndrome, cleft palate, those with obstructive apnea-hypopnea index > 50% of total apnea-hypopnea index, or with underlying cardiac or pulmonary parenchymal pathology were excluded. Polysomnography parameters were extracted for periods both on and off supplemental oxygenation.
Fifty-two (mean [standard deviation] age at polysomnography 32.6 [34.7] days; 21 females) term infants were included. There was a statistically significant improvement in apnea-hypopnea index on supplemental oxygen (mean [standard deviation] in room air 50.2 [36.3] vs 11.6 [9], < .001 on supplemental oxygen), in both rapid eye movement and nonrapid eye movement sleep, as well as in mean oxygen saturations (96.6% in room air to 98.9% on oxygen; < .001). There was no statistically significant change in transcutaneous carbon dioxide levels or sleep duration. Oxygenation was prescribed for a median (interquartile range) age of 197 (127) days.
Central sleep apnea in term infants who are otherwise healthy generally has a good prognosis, with oxygen therapy prescribed for around 6 months. Oxygen therapy was associated with improved saturations and decrease in apnea-hypopnea index when assessed with polysomnography.
Hayashi A, Suresh S, Kevat A, Robinson J, Kapur N. Central sleep apnea in otherwise healthy term infants. . 2022; 18(12):2813-2817.
描述健康足月婴儿中枢性睡眠呼吸暂停需家庭补充氧疗的结局。
回顾性分析 2015 年至 2020 年在昆士兰儿童医院行多导睡眠图检查的所有<1 岁儿童。排除胎龄<37 周、有基础综合征、腭裂、阻塞性睡眠呼吸暂停低通气指数>50%总呼吸暂停低通气指数或有基础心脏或肺实质病变的患儿。提取多导睡眠图检查期间（包括吸氧和不吸氧期间）的参数。
共纳入 52 例（平均[标准差]多导睡眠图检查时年龄为 32.6[34.7]天；21 例女性）足月婴儿。补充氧后呼吸暂停低通气指数显著改善（在空气中为 50.2[36.3]，在氧中为 11.6[9]， <.001），无论是快动眼睡眠还是非快动眼睡眠，以及平均氧饱和度（在空气中为 96.6%，在氧中为 98.9%； <.001）均显著改善。经皮二氧化碳水平或睡眠时间无统计学意义变化。中位（四分位间距）吸氧年龄为 197（127）天。
健康足月婴儿中枢性睡眠呼吸暂停一般预后良好，氧疗时间约为 6 个月。多导睡眠图检查时，氧疗与饱和度升高和呼吸暂停低通气指数降低相关。
Hayashi A, Suresh S, Kevat A, Robinson J, Kapur N. 健康足月婴儿中枢性睡眠呼吸暂停.. 2022; 18(12):2813-2817.
