通往阻塞性睡眠呼吸暂停个性化医疗方法的征程：成人阻塞性睡眠呼吸暂停的类似方法能否应用于儿童阻塞性睡眠呼吸暂停？
Journey towards a personalised medicine approach for OSA: Can a similar approach to adult OSA be applied to paediatric OSA?
作者信息
Siriwardhana Leon S, Nixon Gillian M, Horne Rosemary S C, Edwards Bradley A
机构信息
The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, Australia.
The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, Australia; Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Australia.
出版信息
Paediatr Respir Rev. 2020 Nov;36:128-135. doi: 10.1016/j.prrv.2020.01.002. Epub 2020 Feb 14.
The concept of personalised medicine is likely to revolutionise the treatment of adult obstructive sleep apnoea as a result of recent advances in the understanding of disease heterogeneity by identifying clinical phenotypes, pathophysiological endotypes, biomarkers and treatable traits. Children with the condition show a similar level of heterogeneity and paediatric obstructive sleep apnoea would also benefit from a more targeted approach to diagnosis and management. This review aims to summarise the adult literature on the phenotypes and endotypes of obstructive sleep apnoea and assess whether a similar approach may also be suitable to guide the development of new diagnostic and management approaches for paediatric obstructive sleep apnoea.
由于在通过识别临床表型、病理生理内型、生物标志物和可治疗特征来理解疾病异质性方面取得了最新进展，个性化医疗的概念可能会彻底改变成人阻塞性睡眠呼吸暂停的治疗方法。患有这种疾病的儿童也表现出相似程度的异质性，小儿阻塞性睡眠呼吸暂停也将受益于更具针对性的诊断和管理方法。本综述旨在总结关于阻塞性睡眠呼吸暂停表型和内型的成人文献，并评估类似的方法是否也适用于指导小儿阻塞性睡眠呼吸暂停新诊断和管理方法的开发。
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