Huang Rong, Zhou Guicheng, Cai Jie, Cao Cha, Zhu Zhenjun, Wu Qingping, Zhang Fen, Ding Yu
Department of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.
Gut Microbes. 2025 Dec;17(1):2483783. doi: 10.1080/19490976.2025.2483783. Epub 2025 Apr 2.
Urbanization has significantly transformed dietary habits worldwide, contributing to a globally increased burden of non-communicable diseases and altered gut microbiota landscape. However, it is often overlooked that the adverse effects of these dietary changes can be transmitted from the mother to offspring during early developmental stages, subsequently influencing the predisposition to various diseases later in life. This review aims to delineate the detrimental effects of maternal urban-lifestyle diet (urbanized diet) on early-life health and gut microbiota assembly, provide mechanistic insights on how urbanized diet mediates mother-to-offspring transfer of bioactive substances in both intrauterine and extrauterine and thus affects fetal and neonatal development. Moreover, we also further propose a framework for developing microbiome-targeted precision nutrition and diet strategies specifically for pregnant and lactating women. The establishment of such knowledge can help develop proactive preventive measures from the beginning of life, ultimately reducing the long-term risk of disease and improving public health outcomes.
城市化已显著改变了全球的饮食习惯，导致全球非传染性疾病负担增加，并改变了肠道微生物群格局。然而，人们常常忽视的是，这些饮食变化的不良影响在早期发育阶段可从母亲传给后代，进而影响其日后患各种疾病的易感性。本综述旨在阐述母亲的城市生活方式饮食（城市化饮食）对生命早期健康和肠道微生物群组装的有害影响，提供关于城市化饮食如何在子宫内和子宫外介导生物活性物质从母亲到后代的转移，从而影响胎儿和新生儿发育的机制见解。此外，我们还进一步提出了一个框架，用于制定专门针对孕妇和哺乳期妇女的以微生物群为靶点的精准营养和饮食策略。建立这样的知识有助于从生命伊始就制定积极的预防措施，最终降低疾病的长期风险并改善公共卫生结果。
