Chakraborty T K, Bhatia D, Heading R C, Ford M J
Gut. 1987 May;28(5):613-5. doi: 10.1136/gut.28.5.613.
The oral administration of mesalazine (5-aminosalicylic acid) resulted in the exacerbation of ulcerative colitis in two patients intolerant to sulphasalazine whose colitis had previously been quiescent. Although sulphasalazine intolerance is usually attributable to the sulphapyridine moiety, the possibility of salicylate sensitivity should be considered in colitic patients who fail to respond appropriately to sulphasalazine or who experience abdominal pain or diarrhoea while taking the drug.
两名对柳氮磺胺吡啶不耐受且此前结肠炎已缓解的患者，口服美沙拉嗪（5-氨基水杨酸）后，溃疡性结肠炎病情加重。虽然柳氮磺胺吡啶不耐受通常归因于磺胺吡啶部分，但对于对柳氮磺胺吡啶反应不佳或在服用该药时出现腹痛或腹泻的结肠炎患者，应考虑水杨酸盐敏感性的可能性。
