Bursa Uludag University, Vocational School of Health Services, 16059, Bursa, Turkey.
Bursa Uludag University, Department of Biology, Science and Art Faculty, 16059, Bursa, Turkey.
Mitochondrion. 2022 Sep;66:74-81. doi: 10.1016/j.mito.2022.08.002. Epub 2022 Aug 10.
Breast cancer is the most common cancer in women worldwide. MicroRNAs (miRNAs) are non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. Although miRNAs mainly act in the cytoplasm, they can be found in the mitochondrial compartment of the cell. These miRNAs called "MitomiR", they can change mitochondrial functions by regulating proteins at the mitochondrial level and cause cancer. In this review, we have aimed to explain miRNA biogenesis, transport pathways to mitochondria, and summarize mitomiRs that have been shown to play an important role in mitochondrial function, especially in the initiation and progression of breast cancer.
乳腺癌是全球女性最常见的癌症。microRNAs（miRNAs）是一种非编码 RNA，参与基因表达的转录后调控。尽管 miRNAs 主要在细胞质中发挥作用，但它们也可以在细胞的线粒体隔室中找到。这些被称为“MitomiR”的 miRNAs 可以通过调节线粒体水平的蛋白质来改变线粒体功能，并导致癌症。在这篇综述中，我们旨在解释 miRNA 的生物发生、运输到线粒体的途径，并总结已被证明在线粒体功能中发挥重要作用的 mitomiRs，特别是在乳腺癌的发生和发展中。
