HM CINAC, Centro Integral de Neurociencias AC. Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain; CIBERNED, Instituto de Salud Carlos III, Madrid, Spain; Ph.D. Program in Neuroscience, Universidad Autónoma de Madrid Cajal Institute, Madrid 28029, Spain.
Department of Psychology, University of Sheffield, Sheffield S10 2TN, UK.
Neurosci Biobehav Rev. 2022 Oct;141:104826. doi: 10.1016/j.neubiorev.2022.104826. Epub 2022 Aug 11.
The dorsolateral striatum plays a critical role in the acquisition and expression of stimulus-response habits that are learned in experimental laboratories. Here, we use meta-analytic procedures to contrast the neural circuits activated by laboratory-acquired habits with those activated by stimulus-response behaviours acquired in everyday-life. We confirmed that newly learned habits rely more on the anterior putamen with activation extending into caudate and nucleus accumbens. Motor and associative components of everyday-life habits were identified. We found that motor-dominant stimulus-response associations developed outside the laboratory primarily engaged posterior dorsal putamen, supplementary motor area (SMA) and cerebellum. Importantly, associative components were also represented in the posterior putamen. Thus, common neural representations for both naturalistic and laboratory-based habits were found in the left posterior and right anterior putamen. These findings suggest a partial common striatal substrate for habitual actions that are performed predominantly by stimulus-response associations represented in the posterior striatum. The overlapping neural substrates for laboratory and everyday-life habits supports the use of both methods for the analysis of habitual behaviour.
背外侧纹状体在获取和表达在实验室内习得的刺激-反应习惯方面起着关键作用。在这里，我们使用荟萃分析程序来对比实验室习得的习惯所激活的神经回路与日常生活中习得的刺激-反应行为所激活的神经回路。我们证实，新习得的习惯更多地依赖于前壳核，激活延伸到尾状核和伏隔核。确定了日常生活习惯的运动和联想成分。我们发现，实验室外发展起来的以运动为主导的刺激-反应关联主要涉及后背侧壳核、补充运动区（SMA）和小脑。重要的是，后壳核也有联想成分。因此，自然习惯和基于实验室的习惯的共同神经表现都在前背和右前壳核。这些发现表明，习惯行为的背外侧纹状体存在部分共同纹状体基础，这些行为主要通过刺激-反应关联来表现，这些关联在后纹状体中得到体现。实验室和日常生活习惯的重叠神经基础支持了这两种方法在习惯行为分析中的应用。
