Michaeli J, Admon D, Lugassy G, Matzner Y
Haemostasis. 1987;17(1-2):105-8. doi: 10.1159/000215565.
We describe a patient with iron-deficiency anemia, thrombocytopenia and paucity of marrow megakaryocytes, in whom the anemia and the thrombocytopenia responded to the administration of iron. Thrombocytopenia recurred, despite maintenance of normal hemoglobin and iron levels and adequate marrow megakaryocytes. Corticosteroids and splenectomy were required for the control of the thrombocytopenia. In this patient, the initial manifestations of idiopathic thrombocytopenic purpura were modified by the presence of severe iron deficiency. This case strengthens the contention that iron is essential for megakaryopoiesis and thrombopoiesis.
我们描述了一名患有缺铁性贫血、血小板减少症且骨髓巨核细胞缺乏的患者，该患者的贫血和血小板减少症对铁剂治疗有反应。尽管维持了正常的血红蛋白和铁水平以及充足的骨髓巨核细胞，但血小板减少症仍复发。需要使用皮质类固醇和脾切除术来控制血小板减少症。在该患者中，严重缺铁改变了特发性血小板减少性紫癜的初始表现。这个病例强化了铁对巨核细胞生成和血小板生成至关重要的观点。
