Sakurai T, Kono I, Kabashima T, Yamane K, Nagasawa T, Kashiwagi H
Jpn J Med. 1984 May;23(2):135-8. doi: 10.2169/internalmedicine1962.23.135.
A patient with systemic lupus erythematosus (SLE) developed amegakaryocytic thrombocytopenic purpura. The absence of a drug relationship or other identifiable underlying cause made us consider this to be a rare manifestation of SLE. Her thrombocytopenia, which initially appeared to be steroid-resistant, ultimately improved following a prolonged high-dose prednisolone therapy. To our knowledge, this is the second case of amegakaryocytic thrombocytopenia associated with SLE in the literature. The possibility that amegakaryocytic thrombocytopenia in SLE can be caused by cellular rather than humoral immunologic mechanism was discussed.
一名系统性红斑狼疮（SLE）患者出现了无巨核细胞性血小板减少性紫癜。由于不存在药物关联或其他可识别的潜在病因，我们认为这是SLE的一种罕见表现。她的血小板减少症最初似乎对类固醇耐药，但在长期高剂量泼尼松龙治疗后最终有所改善。据我们所知，这是文献中第二例与SLE相关的无巨核细胞性血小板减少症病例。本文讨论了SLE中的无巨核细胞性血小板减少症可能由细胞免疫机制而非体液免疫机制引起的可能性。
