你在干扰素调节因子（IRF）家族中属于哪一种？干扰素调节因子 8（IRF8）缺陷导致浆细胞样树突状细胞（pDC）谱系定向分化受阻。
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment.
机构信息
Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium.
Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium; Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.
出版信息
Trends Immunol. 2022 Sep;43(9):687-689. doi: 10.1016/j.it.2022.07.007. Epub 2022 Aug 10.
Interferon regulatory factor 8 (IRF8) has long been associated with conventional dendritic cell type I (cDC1) development. In a recent study, Lança et al. demonstrate that IRF8 is also crucial in cells already committed to the cDC1 lineage. Here, deletion of IRF8 from the XCR1-expressing pre-cDC1 stage onward leads to a loss of commitment and reprogramming of the cells toward a cDC2-like phenotype.
干扰素调节因子 8（IRF8）长期以来一直与传统的树突状细胞 I 型（cDC1）的发育有关。在最近的一项研究中，Lança 等人证明，IRF8 对于已经定向到 cDC1 谱系的细胞也至关重要。在这里，从表达 XCR1 的 pre-cDC1 阶段开始，IRF8 的缺失会导致细胞的定向丧失和重编程，向 cDC2 样表型发展。
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