Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.
Prev Vet Med. 2022 Nov;208:105730. doi: 10.1016/j.prevetmed.2022.105730. Epub 2022 Jul 30.
Duck hepatitis A virus (DHAV) is a single-strand positive-sense small RNA virus that causes high mortality in ducklings. In recent years, the incidence of DHAV-3 subtype has been increasing in China, leading to great economic losses to the duck-breeding industry. We investigated the incidence and mortality rates of DHAV in ducks and analysed the seroprevalence of DHAV in mainland China, by meta-analysis. Twenty-six studies published between 2009 and 2021 were retrieved, with a total of 689,549 cases from 14 provinces. Using the DerSimonian-Laird model, DHAV prevalence was estimated with the variance-stabilizing double arcsine transformation. The incidence of DHAV in mainland China was 12 % (95 % confidence interval [CI]: 3-20 %), and the mortality rate was 11 % (95 % CI: 2-19 %), suggesting that the virus was highly virulent and mortality was high. Time analysis showed that DHAV incidence decreased over time. The typing survey showed that strains of DHAV-1 serotype accounted for 38 % (95 % CI: 21-56 %) and strains of DHAV-3 serotype accounted for 49 % (95 % CI: 31-68%) of the tested samples. The decline in the detection rate of DHAV-1 may be due to the widespread use of the DHAV-1 vaccine, which has effectively controlled the DHAV-1 serotype virus. The DHAV-3 vaccine has been on the market for a short time and has no cross protection with DHAV-1, so DHAV-3 accounted for a high proportion of the tested samples. Subgroup analysis of the detection methods showed little difference between PCR and other detection methods.
鸭甲型肝炎病毒（DHAV）是一种单链正链小 RNA 病毒，可导致雏鸭高死亡率。近年来，中国 DHAV-3 亚群的发病率不断上升，给养鸭业造成了巨大的经济损失。我们通过荟萃分析调查了鸭 DHAV 的发病率和死亡率，并分析了中国大陆 DHAV 的血清流行率。共检索到 2009 年至 2021 年期间发表的 26 项研究，来自 14 个省的 689549 例病例采用 DerSimonian-Laird 模型，使用方差稳定双反正弦变换估计 DHAV 患病率。中国大陆 DHAV 的发病率为 12%（95%置信区间[CI]：3-20%），死亡率为 11%（95%CI：2-19%），提示该病毒毒力较强，死亡率较高。时间分析显示，DHAV 的发病率随时间呈下降趋势。分型调查显示，DHAV-1 血清型毒株占 38%（95%CI：21-56%），DHAV-3 血清型毒株占 49%（95%CI：31-68%）。DHAV-1 检出率下降可能是由于 DHAV-1 疫苗的广泛使用，该疫苗有效控制了 DHAV-1 血清型病毒。DHAV-3 疫苗上市时间较短，与 DHAV-1 无交叉保护作用，因此 DHAV-3 占检测样本的比例较高。检测方法的亚组分析表明，PCR 与其他检测方法之间差异不大。
