Robertson I, Cook M G
Histopathology. 1987 Apr;11(4):395-402. doi: 10.1111/j.1365-2559.1987.tb02644.x.
An uncommon form of presentation of melanocytic dysplasia is described in 15 patients with primary cutaneous melanoma and a high incidence of multiple melanomas. This variation in melanocytic dysplasia appears macroscopically to the pathologist and to the clinician as a diffuse mottling or 'freckling' of the widely excised skin around the melanomas. Most patients also were described clinically as having multiple moles in other sites as well as round the melanoma. Histologically, the abnormally pigmented skin of the wider excisions has the features of melanocytic dysplasia, usually of lentiginous type, and this is seen both in continuity with the melanoma and distant from it including the margins of the wider excisions. These patients seem particularly prone to developing additional primary melanomas and therefore recognition of this form of presentation of melanocytic dysplasia may be important in patient management and prophylactic care of their families.
本文描述了15例原发性皮肤黑色素瘤患者中黑色素细胞发育异常的一种不常见表现形式，这些患者多发黑色素瘤的发生率较高。这种黑色素细胞发育异常的变异在病理学家和临床医生看来，宏观上表现为黑色素瘤周围广泛切除皮肤的弥漫性斑点或“雀斑样”改变。大多数患者在临床上还被描述为除黑色素瘤周围外，身体其他部位也有多发痣。组织学上，广泛切除组织中色素异常的皮肤具有黑色素细胞发育异常的特征，通常为雀斑样型，在与黑色素瘤连续的部位以及远离黑色素瘤的部位包括广泛切除组织的边缘均可看到。这些患者似乎特别容易发生额外的原发性黑色素瘤，因此识别这种黑色素细胞发育异常的表现形式可能对患者管理及其家族的预防性护理很重要。
