哮喘-慢性阻塞性肺疾病重叠综合征的生理学
The Physiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap.
作者信息
Kaminsky David A, Irvin Charles G
机构信息
Pulmonary and Critical Care Medicine, University of Vermont Larner College of Medicine, Given D213, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Pulmonary and Critical Care Medicine, University of Vermont Larner College of Medicine, HSRF 226, 149 Beaumont Avenue, Burlington, VT 05405, USA.
出版信息
Immunol Allergy Clin North Am. 2022 Aug;42(3):575-589. doi: 10.1016/j.iac.2022.04.001. Epub 2022 Jun 30.
Asthma and chronic obstructive pulmonary disease (COPD) are both characterized by airway obstruction and share similar clinical manifestations. However, they differ in many respects related to underlying cause, mechanism of airway obstruction, pattern and progression of symptoms, and response to therapy. It remains unclear whether there is a unique physiologic phenotype that characterizes asthma-COPD overlap (ACO). This review describes the common and distinct physiologic tests that help define asthma and COPD and potentially how they may contribute to understanding the underlying physiology of ACO.
哮喘和慢性阻塞性肺疾病（COPD）均以气道阻塞为特征，且具有相似的临床表现。然而，它们在许多方面存在差异，包括潜在病因、气道阻塞机制、症状模式及进展，以及对治疗的反应。目前尚不清楚是否存在一种独特的生理表型来表征哮喘-慢性阻塞性肺疾病重叠综合征（ACO）。本综述描述了有助于定义哮喘和慢性阻塞性肺疾病的常见和独特的生理测试，以及它们可能如何有助于理解ACO的潜在生理学机制。
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