哮喘-慢性阻塞性肺疾病重叠：过敏的作用。
Asthma-Chronic Obstructive Pulmonary Disease Overlap: The Role for Allergy.
机构信息
Department of Molecular Biology, Princeton University, 7696 Frist Campus Center, Princeton, NJ 08544, USA.
Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
出版信息
Immunol Allergy Clin North Am. 2022 Aug;42(3):591-600. doi: 10.1016/j.iac.2022.04.002. Epub 2022 Jun 30.
Asthma and chronic obstructive pulmonary disease (COPD) are 2 distinct diseases with different clinical presentations. Chronic inflammation and airway obstruction are key features of asthma and COPD. Increased morbidity and mortality rates seem to be an important characteristic associated with asthma-COPD overlap (ACO).Atopy is an important clinical characteristic of patients categorized as ACO. Herein, the authors review the recent advancements in basic research, clinical assessment, and defining characteristics of ACO and the role for allergy as well as highlight future potential for disease-specific therapeutics for this asthma subtype.
哮喘和慢性阻塞性肺疾病（COPD）是两种具有不同临床表现的截然不同的疾病。慢性炎症和气道阻塞是哮喘和 COPD 的关键特征。发病率和死亡率的增加似乎是与哮喘-COPD 重叠（ACO）相关的一个重要特征。特应性是归类为 ACO 的患者的重要临床特征。在此，作者回顾了 ACO 的基础研究、临床评估和定义特征方面的最新进展以及过敏的作用，并强调了这种哮喘亚型的疾病特异性治疗的未来潜力。
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