Faculty of Agriculture, Kagawa University.
Research and Development, Matsutani Chemical Industry Co., Ltd.
J Oleo Sci. 2022 Sep 1;71(9):1387-1395. doi: 10.5650/jos.ess22116. Epub 2022 Aug 15.
d-Allulose (d-psicose) is a rare sugar, that contains no calories and exhibits 70% relative sweetness when compared with sucrose. Recently, several studies have demonstrated the anti-obesity effect of d-allulose, mediated by suppressing lipogenesis and increasing energy expenditure. Medium-chain triacylglycerols (MCTs) are lipids formed by 3 medium-chain fatty acids (MCFAs) with 6-12 carbon atoms attached to glycerol. MCTs have been expensively studied to reduce body fat accumulation in rats and humans. The anti-obesity effect of MCTs was not confirmed depending on the nutritional conditions because MCT might promote lipogenesis. In the present study, we examined the effects of simultaneous intake of diets containing low (5%) or high (13%) MCTs, with or without 5% d-allulose, on body fat accumulation in rats (Experiment 1). Furthermore, we assessed the interaction between 5% MCT and 5% d-allulose in the diet (Experiment 2). In Experiment 1, intra-abdominal adipose tissue weight was significantly greater in the high MCT diet groups than in the commercial diet (control) group. d-Allulose significantly decreased weights of intra-abdominal adipose tissue, carcass fat, and total body fat, however, these weights increased as the amount of MCT added increased. In Experiment 2, d-allulose significantly decreased almost all body fat indicators, and these values were not influenced by the presence or absence of MCT addition. The anti-obesity effect of d-allulose was observed with or without dietary MCT, and no synergistic effect was detected between d-allulose and MCT. These results suggest that d-allulose is a beneficial food ingredient in diets aimed at reducing body fat accumulation. However, further research is required on the synergistic effects between d-allulose and MCTs.
d-阿洛酮糖（d-阿洛糖）是一种稀有糖，它不含热量，与蔗糖相比甜度相对为 70%。最近，几项研究表明，d-阿洛酮糖通过抑制脂肪生成和增加能量消耗来发挥抗肥胖作用。中链三酰甘油（MCT）是由 3 个中链脂肪酸（MCFA）与甘油结合而成的脂质，MCFA 含有 6-12 个碳原子。MCT 已被昂贵地研究用于减少大鼠和人类的体脂肪积累。然而，由于 MCT 可能促进脂肪生成，因此其抗肥胖作用取决于营养条件而未得到证实。在本研究中，我们研究了同时摄入含有低（5%）或高（13%）MCT 的饮食，以及是否含有 5%d-阿洛酮糖对大鼠体脂肪积累的影响（实验 1）。此外，我们评估了饮食中 5% MCT 和 5%d-阿洛酮糖之间的相互作用（实验 2）。在实验 1 中，高 MCT 饮食组的腹腔内脂肪组织重量明显大于商业饮食（对照）组。d-阿洛酮糖显著降低了腹腔内脂肪组织、胴体脂肪和总体脂肪的重量，但随着 MCT 添加量的增加，这些重量增加。在实验 2 中，d-阿洛酮糖显著降低了几乎所有的体脂肪指标，而 MCT 的存在与否对这些值没有影响。d-阿洛酮糖具有抗肥胖作用，无论是否添加 MCT，并且在 d-阿洛酮糖和 MCT 之间未检测到协同作用。这些结果表明，d-阿洛酮糖是旨在减少体脂肪积累的饮食中的有益食品成分。然而，需要进一步研究 d-阿洛酮糖和 MCTs 之间的协同作用。
