Faculty of Human Sciences, Hokkaido Bunkyo University.
Faculty of Nutrition, University of Kochi.
J Nutr Sci Vitaminol (Tokyo). 2022;68(4):348-352. doi: 10.3177/jnsv.68.348.
Allitol is a rare sugar alcohol obtained by reducing d-allulose (d-psicose). However, information on the effects of long-term dietary allitol intake is limited. This study aimed to investigate the effect of allitol supplementation, as a sugar substitute, on body fat accumulation in rats compared with sucrose, rare sugar d-allulose, or erythritol. Thirty-two male Wistar rats (3 wk old) were fed experimental diets including 5% sucrose, allitol, erythritol, or d-allulose for 8 wk ad libitum. Weight gain, food intake, and food efficiency did not differ among the groups. The total body fat mass and percentage, and intra-abdominal adipose tissue weights were significantly lower in rats fed with the allitol diet than in those fed with the sucrose diet. These body fat indicators tended to be lower in rats fed with the erythritol and d-allulose diets than in those fed with the sucrose diet, but there was no significant difference. The serum glucose-lowering effect obtained in rats fed with the d-allulose diet did not appear in rats fed with the allitol diet. These results suggest that the anti-obesity effect of allitol may be equal to or greater than that of d-allulose.
阿糖醇是一种通过还原 D-阿洛酮糖（D-塔格糖）得到的稀有糖醇。然而，长期摄入阿糖醇的饮食影响的相关信息有限。本研究旨在比较阿糖醇作为糖替代品与蔗糖、稀有糖 D-阿洛酮糖或赤藓糖醇对大鼠体脂肪积累的影响。32 只雄性 Wistar 大鼠（3 周龄）自由摄取含 5%蔗糖、阿糖醇、赤藓糖醇或 D-阿洛酮糖的实验饮食 8 周。各组间体重增加、食物摄入量和食物效率无差异。与喂食蔗糖饮食的大鼠相比，喂食阿糖醇饮食的大鼠总体脂肪量和百分比以及腹腔内脂肪组织重量显著降低。与喂食蔗糖饮食的大鼠相比，喂食赤藓糖醇和 D-阿洛酮糖饮食的大鼠的这些体脂指标呈降低趋势，但无统计学差异。在喂食 D-阿洛酮糖饮食的大鼠中观察到的降血糖作用并未出现在喂食阿糖醇饮食的大鼠中。这些结果表明，阿糖醇的抗肥胖作用可能与 D-阿洛酮糖相当或更大。
