Erdman John W
Department of Food Science and Human Nutrition, University of Illinois, 455 Bevier Hall, 905 S. Goodwin Ave, Urbana, IL, 61801, USA.
Mol Aspects Med. 2023 Feb;89:101116. doi: 10.1016/j.mam.2022.101116. Epub 2022 Aug 11.
Our food supply contains a range of essential and non-essential food components. There are substantial epidemiologic findings and additional clinical data to support the health benefits for some non-essential food components - these compounds are often referred to as bioactives. While there is a well-established process in place to make science-based dietary recommendations for essential nutrients, this is not the case for bioactive food components. This manuscript reviews the evolution of the RDAs and the transition to a DRI framework for establishing requirements for essential nutrients. Then, the potential of development of public health recommendations for bioactives will be explored and the benefits and challenges of making recommendations will be presented. The scientific support for case studies for lutein and flavan-3-ols, will be made. Finally, suggestions for frameworks that might be considered by authoritative policy-making bodies when evaluating the efficacy and safely of proposed bioactives will be discussed.
我们的食物供应包含一系列必需和非必需的食物成分。有大量的流行病学研究结果和其他临床数据支持某些非必需食物成分对健康有益——这些化合物通常被称为生物活性物质。虽然已有一套完善的流程来为必需营养素制定基于科学的饮食建议，但生物活性食物成分并非如此。本文回顾了推荐膳食摄入量（RDAs）的演变以及向用于确定必需营养素需求的膳食参考摄入量（DRI）框架的转变。然后，将探讨制定生物活性物质公共卫生建议的可能性，并阐述提出建议的益处和挑战。还将提供叶黄素和黄烷 - 3 - 醇案例研究的科学依据。最后，将讨论权威决策机构在评估拟议生物活性物质的功效和安全性时可能考虑的框架建议。
