Shanxi Key Lab. for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
College of Pharmacy, Heze University, Heze, Shangdong, 274000, People's Republic of China.
BMC Vet Res. 2022 Aug 15;18(1):311. doi: 10.1186/s12917-022-03392-4.
In the livestock feed industry, feed and feed raw materials are extremely susceptible to mycotoxin contamination. Deoxynivalenol (DON) is one of the main risk factors for mycotoxin contamination in broiler feed and feedstuff, however, there is still little knowledge about this. Hence, the purpose of this study was to explore the toxicity effect of DON on the intestinal barrier and the microecological balance of the biota in broiler chickens.
In our present study, we compared the pathological scores of the small intestines of broilers on the 5, 7, and 10 day, and chose the 7 day to analyze the small intestine histomorphology, tight junctions, and cecal biota of the broilers. The results showed the damage to the small intestine worsened over time, the small intestinal villi of broilers were breakage, the tight junctions of the small intestine were destroyed, the cecal biota was unbalanced, and the growth performance of broilers was reduced on the 7 day.
DON could damage the functional and structural completeness of the intestinal tract, disorder the Intestinal biota, and finally lead to declined broiler performance. Our study provided a basis for the prevention and treatment of DON in broiler production.
在畜牧业饲料行业，饲料和饲料原料极易受到霉菌毒素污染。脱氧雪腐镰刀菌烯醇（DON）是肉鸡饲料和饲料中霉菌毒素污染的主要风险因素之一，但目前对此知之甚少。因此，本研究旨在探讨 DON 对肉鸡肠道屏障和生物群落微生态平衡的毒性作用。
在本研究中，我们比较了肉鸡第 5、7 和 10 天的小肠病理评分，并选择第 7 天来分析肉鸡的小肠组织形态学、紧密连接和盲肠生物群落。结果表明，小肠损伤随时间恶化，肉鸡的小肠绒毛断裂，小肠紧密连接被破坏，盲肠生物群落失衡，肉鸡的生长性能下降。
DON 可破坏肠道的功能和结构完整性，扰乱肠道微生物群落，最终导致肉鸡生产性能下降。本研究为肉鸡生产中 DON 的预防和治疗提供了依据。
