Zhu Ling, Geng Jiawei, Xiao An
Department of Infectious Diseases and Hepatic Diseases, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, China.
J Biomed Res. 2022 May 28;36(3):215-220. doi: 10.7555/JBR.36.20220044.
gum, the dry exudate of and other members of the same genus, is used as a thickener and emulsifier in foods. It is generally considered safe as a food or drug, and its adverse reactions, such as -induced liver injury, have never been reported. A 46-year-old woman was admitted to hospital with fatigue, nausea, abdominal distension, jaundice and a >16-fold increase in transaminase and bilirubin level. The patient had used gum prior to the onset of her symptoms. Her symptoms and clinical indicators improved after treatment. The possibility of acute viral hepatitis, autoimmune hepatitis, and metabolic liver disease was excluded. After discharge from hospital, the patient had a severe liver injury again when re-exposed to gum. And the Roussel Uclaf Causality Assessment Method score was updated from 5 to 7, which was consistent with probable drug-induced liver injury. This is the first report of -induced liver injury. Clinicians need to be aware of the potential hepatotoxicity of .
没药，没药属植物及其同属其他成员的干燥渗出物，在食品中用作增稠剂和乳化剂。它通常被认为作为食品或药物是安全的，并且从未有过诸如其所致肝损伤等不良反应的报道。一名46岁女性因疲劳、恶心、腹胀、黄疸以及转氨酶和胆红素水平升高超过16倍而入院。该患者在症状出现前使用过没药胶。治疗后其症状和临床指标有所改善。排除了急性病毒性肝炎、自身免疫性肝炎和代谢性肝病的可能性。出院后，患者再次接触没药胶时又出现严重肝损伤。并且罗塞尔·乌克拉夫因果关系评估方法评分从5分更新为7分，这与可能的药物性肝损伤相符。这是没药所致肝损伤的首例报道。临床医生需要意识到没药的潜在肝毒性。
