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一名反复发热且CD4 T细胞缺乏患者的感染:病例报告

infection in a patient with repeated fever and CD4 T cell deficiency: A case report.

作者信息

Hong Xin, Ji You-Qi, Chen Meng-Yuan, Gou Xiao-Yu, Ge Yu-Mei

机构信息

Department of Green Pharmaceutical Collaborative Innovation Center, School of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, Zhejiang Province, China.

School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China.

出版信息

World J Clin Cases. 2023 Feb 16;11(5):1175-1181. doi: 10.12998/wjcc.v11.i5.1175.

Abstract

BACKGROUND

pneumonia shares similar imaging and clinical features with pulmonary tuberculosis and lung neoplasms, but the treatment and anti-infective medication are completely different. Here, we report a case of pulmonary nocardiosis caused by (), which was misdiagnosed as community-acquired pneumonia (CAP) with repeated fever.

CASE SUMMARY

A 55-year-old female was diagnosed with community-acquired pneumonia in the local hospital because of repeated fever and chest pain for two months. After the anti-infection treatment failed in the local hospital, the patient came to our hospital for further treatment. Enhanced computed tomography showed multiple patchy, nodular and strip-shaped high-density shadows in both lungs. A routine haematological examination was performed and showed abnormalities in CD19 B cells and CD4 T cells. Positive acid-fast bifurcating filaments and branching gram-positive rods were observed in the bronchoalveolar lavage fluid of the patient under an oil microscope, which was identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry as The patient's condition quickly improved after taking 0.96 g compound sulfamethoxazole tablets three times a day.

CONCLUSION

The antibiotic treatment of pneumonia is different from that of common CAP. Attention should be given to the pathogenic examination results of patients with recurrent fever. pneumonia is an opportunistic infection. Patients with CD4 T-cell deficiency should be aware of infection.

摘要

背景

肺炎在影像学和临床特征上与肺结核及肺部肿瘤有相似之处,但治疗方法和抗感染用药却完全不同。在此,我们报告一例由()引起的肺诺卡菌病病例,该病例因反复发热被误诊为社区获得性肺炎(CAP)。

病例摘要

一名55岁女性因反复发热和胸痛两个月,在当地医院被诊断为社区获得性肺炎。在当地医院抗感染治疗失败后,患者前来我院进一步治疗。增强计算机断层扫描显示双肺多发斑片状、结节状及条索状高密度影。进行了常规血液学检查,结果显示CD19 B细胞和CD4 T细胞异常。在油镜下观察患者支气管肺泡灌洗液可见抗酸分支丝状物和革兰氏阳性分支杆菌,经基质辅助激光解吸电离飞行时间质谱鉴定为()。患者每日三次服用0.96 g复方磺胺甲恶唑片后病情迅速好转。

结论

()肺炎的抗生素治疗与普通CAP不同。对于反复发热的患者应关注其病原学检查结果。()肺炎是一种机会性感染。CD4 T细胞缺乏的患者应警惕()感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bd/9979296/2811689c04cf/WJCC-11-1175-g001.jpg

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