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一名高免疫球蛋白E综合征患者出现进行性炎症性肺部浸润。

A progressing inflammatory pulmonary infiltrate in a patient with hyper IgE syndrome.

作者信息

Jakobsen Samal, Hilberg Ole, Larsen Carsten Schade, Løkke Anders

机构信息

Department of Pulmonology, Aarhus University Hospital, Aarhus, Denmark.

Department of Pulmonology, Vejle Sygehus, Vejle, Denmark.

出版信息

SAGE Open Med Case Rep. 2022 Aug 6;10:2050313X221116674. doi: 10.1177/2050313X221116674. eCollection 2022.

DOI:10.1177/2050313X221116674
PMID:35966124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9364196/
Abstract

A young man known with autosomal dominant hyper IgE syndrome and changes on his chest radiograph was presumed to be infected with and treated with antifungal medicine for 11 months without effect. Positron emission tomography/computed tomography imaging was suggestive of Aspergilloma but bronchoalveolar lavage cultures, cytology as well as biochemistry were negative for Aspergillus. Finally, a transthoracic computed tomography-guided biopsy did not support the diagnosis of fungal infection as only chronic inflammatory changes were found. The patient was treated with Prednisolone after which the changes on his chest X-ray regressed.

摘要

一名患有常染色体显性高免疫球蛋白E综合征且胸部X光片有变化的年轻男子被推测感染了某种病菌，并接受了11个月的抗真菌药物治疗，但没有效果。正电子发射断层扫描/计算机断层扫描成像提示曲菌球，但支气管肺泡灌洗培养、细胞学检查以及生物化学检查结果显示曲霉菌呈阴性。最后，经胸计算机断层扫描引导下的活检不支持真菌感染的诊断，因为仅发现了慢性炎症变化。该患者接受了泼尼松龙治疗，之后其胸部X光片上的变化有所消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/383324e5cd5e/10.1177_2050313X221116674-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/262c3948a370/10.1177_2050313X221116674-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/88f9cdd4081d/10.1177_2050313X221116674-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/bd42b3141e49/10.1177_2050313X221116674-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/cf0b81814769/10.1177_2050313X221116674-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/78e528b88485/10.1177_2050313X221116674-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/8c683f15014f/10.1177_2050313X221116674-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/383324e5cd5e/10.1177_2050313X221116674-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/262c3948a370/10.1177_2050313X221116674-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/88f9cdd4081d/10.1177_2050313X221116674-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/bd42b3141e49/10.1177_2050313X221116674-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/cf0b81814769/10.1177_2050313X221116674-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/78e528b88485/10.1177_2050313X221116674-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/8c683f15014f/10.1177_2050313X221116674-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc6/9364196/383324e5cd5e/10.1177_2050313X221116674-fig7.jpg

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STAT3 Hyper-IgE Syndrome-an Update and Unanswered Questions.STAT3 高免疫球蛋白 E 综合征：更新与未解问题
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Spectrum of Pulmonary Aspergillosis in Hyper-IgE Syndrome with Autosomal-Dominant STAT3 Deficiency.常染色体显性遗传 STAT3 缺陷导致的高免疫球蛋白 E 综合征中的肺曲霉病谱。
J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1986-1995.e3. doi: 10.1016/j.jaip.2019.02.041. Epub 2019 Mar 13.
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Immunol Cell Biol. 2019 Apr;97(4):368-379. doi: 10.1111/imcb.12209. Epub 2018 Nov 19.
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The spectrum of pulmonary aspergillosis.肺部曲霉菌病的光谱。
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