Sertsu Addisu, Worku Teshager, Fekadu Gelana, Tura Abera Kenay
Department of Nursing, School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Department of Obstetrics and Gynecology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
SAGE Open Med. 2022 Aug 9;10:20503121221116942. doi: 10.1177/20503121221116942. eCollection 2022.
This study aimed to assess the magnitude of chronic kidney disease among patients attending the renal unit of St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Institution-based cross-sectional study was conducted among 620 randomly selected patients who visited St. Paul's Hospital Millennium Medical College renal unit from 1 January to 31 December, 2019. Data on sociodemographic characteristics, clinical conditions, behavioral risk factors, electrolytes, and renal function tests were extracted from patients' medical records. To enter and analyze data, EpiData 3.1 and SPSS 22 were used, respectively. Bivariable and multivariable logistic regression analyses were conducted to see the association between predictor variables and chronic kidney disease. Adjusted odds ratio at 95% confidence interval was used to describe significant association. A -value <0.05 was considered to declare an association between chronic kidney disease and independent variables.
Of 620 patients, 139 (22.4%; 95% confidence interval: 19.2, 25.6) and 61 (9.8%; 95% confidence interval: 7.4, 12.3) had chronic kidney disease using cut-off value of 90 and 60 ml/min/1.73 m, respectively. Having urinary tract obstruction (adjusted odds ratio = 2.32; 95% confidence interval: 1.32, 4.06), hypertension (adjusted odds ratio = 4.06; 95% confidence interval: 2.50, 6.59), diabetes mellitus (adjusted odds ratio = 2.80; 95% confidence interval: 1.62, 4.85), cardiovascular disease (adjusted odds ratio = 2.54; 95% confidence interval: 1.60, 4.01), and age (adjusted odds ratio = 1.83; 95% confidence interval: 1.44, 3.57), family history of chronic kidney disease (adjusted odds ratio = 2.26; 95% confidence interval: 1.36, 3.75) were factors positively associated with having chronic kidney disease.
Nearly, one out of five and one out of ten patients who visited the renal unit had chronic kidney disease using the two thresholds as a cut value. Patients with concomitant urinary tract obstruction, age, hypertension, diabetes mellitus, cardiovascular disease, and a family history of chronic kidney disease were more likely to develop chronic kidney disease. Regular screening for chronic kidney disease, optimal blood sugar, and blood pressure management should be practiced.
本研究旨在评估埃塞俄比亚亚的斯亚贝巴圣保罗医院千禧医学院肾脏科就诊患者中慢性肾脏病的患病程度。
在2019年1月1日至12月31日期间随机选取620名到圣保罗医院千禧医学院肾脏科就诊的患者进行基于机构的横断面研究。从患者病历中提取社会人口学特征、临床状况、行为危险因素、电解质和肾功能检查等数据。分别使用EpiData 3.1和SPSS 22录入和分析数据。进行双变量和多变量逻辑回归分析以观察预测变量与慢性肾脏病之间的关联。采用95%置信区间的调整比值比来描述显著关联。P值<0.05被认为可表明慢性肾脏病与自变量之间存在关联。
在620名患者中，分别采用90和60 ml/min/1.73 m²的截断值时，有139名（22.4%；95%置信区间：19.2，25.6）和61名（9.8%；95%置信区间：7.4，12.3）患有慢性肾脏病。患有尿路梗阻（调整比值比=2.32；95%置信区间：1.32，4.06）、高血压（调整比值比=4.06；95%置信区间：2.50，6.59）、糖尿病（调整比值比=2.80；95%置信区间：1.62，4.85）、心血管疾病（调整比值比=2.54；95%置信区间：1.60，4.01）以及年龄（调整比值比=1.83；95%置信区间：1.44，3.57）、慢性肾脏病家族史（调整比值比=2.26；95%置信区间：1.36，3.75）是与患有慢性肾脏病呈正相关的因素。
将近五分之一和十分之一到肾脏科就诊的患者分别采用这两个阈值作为截断值时患有慢性肾脏病。伴有尿路梗阻、年龄、高血压、糖尿病、心血管疾病以及有慢性肾脏病家族史的患者更易患慢性肾脏病。应开展慢性肾脏病的定期筛查以及血糖和血压的优化管理。
