Department of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
Department of pediatrics and child health, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
BMC Nephrol. 2024 Jan 30;25(1):44. doi: 10.1186/s12882-024-03464-7.
Chronic kidney disease (CKD) is a major public health issue with an increasing incidence and prevalence worldwide. In CKD, hematological parameters are influenced, and the effect increases with CKD stage. Thus, the aim of this study was to assess hematological profile of children with CKD on follow up at Tikur Anbessa Specialized Hospital and St. Paul's Hospital Millennium Medical College in Addis Ababa, Ethiopia.
A cross-sectional study was carried out from March 1 to June 30, 2021 among 238 children with CKD. EDTA tubes were used to collect 4 ml blood samples, which were then examined by Beckman Coulter automated hematology analyzer. SPSS Version 20 was used for statistical analysis, and a bivariate and multivariate regression model were applied to assess correlations. Mean and standard deviation was used to determine hematological profiles.
The total number of patients in the study were 238, with 42 (59.7%) of them being men. The majority of the patients (81%) had CKD stage 1. Mean ± standard deviation determined for white blood cell (WBC) parameters in (thousand/µL); WBC, Neutrophil, Lymphocytes, Eosinophil, Monocytes and Basophil were 8.93 ± 3.32, 4.6 ± 8.31, 2.79 ± 1.62, 0.31 ± 0.51, 0.50 ± 3.03 and 0.03 ± 0.24, respectively. For some of red blood cell (RBC) parameters; RBC (million/ µL), Hemoglobin (Hgb) (g/dL), Hematocrit (Hct) (%) and Mean cell volume (fl.) were 4.73 ± 0.87, 12.82 ± 2.76, 38.28 ± 7.53 and 80.32 ± 7.89, respectively. For the platelet count (PLT) (thousand/µL) and Mean Platelet volume (MPV) (fL) 349.34 ± 130.18 and 9.03 ± 4.31 were determined, respectively. This study also found hematologic parameters such as RBC, HGB, HCT and MPV were found to be positively correlated with eGFR with a P-value < 0.05 for all parameters.
The study found that the majority of study participants were in stages 1 to 3 based on their estimated glomerular filtration rate (eGFR). Some of hematological parameters found to have positive correlation with eGFR. There is a need to improve multiple aspects of CKD management, including routine hematological tests for children with chronic kidney disease.
慢性肾脏病（CKD）是一个日益严重的全球公共卫生问题，其发病率和患病率不断上升。在 CKD 中，血液学参数受到影响，且影响随 CKD 阶段的增加而增加。因此，本研究旨在评估在埃塞俄比亚亚的斯亚贝巴提克里安安巴塞萨专科医院和圣保罗医院千年医科大学接受随访的 CKD 儿童的血液学特征。
本研究是一项横断面研究，于 2021 年 3 月 1 日至 6 月 30 日期间进行，纳入了 238 名 CKD 儿童。使用 EDTA 管采集 4ml 血样，然后使用贝克曼库尔特自动化血液分析仪进行检查。采用 SPSS 版本 20 进行统计分析，并应用双变量和多变量回归模型评估相关性。使用均值和标准差来确定血液学特征。
本研究共纳入 238 例患者，其中 42 例（59.7%）为男性。大多数患者（81%）处于 CKD 1 期。白细胞（WBC）参数的均值±标准差为（千/µL）；WBC、中性粒细胞、淋巴细胞、嗜酸性粒细胞、单核细胞和嗜碱性粒细胞分别为 8.93±3.32、4.6±8.31、2.79±1.62、0.31±0.51、0.50±3.03 和 0.03±0.24。一些红细胞（RBC）参数的均值±标准差为；RBC（百万/µL）、血红蛋白（Hgb）（g/dL）、血细胞比容（Hct）（%）和平均红细胞体积（fl.）分别为 4.73±0.87、12.82±2.76、38.28±7.53 和 80.32±7.89。血小板计数（PLT）（千/µL）和平均血小板体积（MPV）（fL）分别为 349.34±130.18 和 9.03±4.31。本研究还发现，RBC、HGB、Hct 和 MPV 等血液学参数与 eGFR 呈正相关，所有参数的 P 值均<0.05。
本研究发现，大多数研究参与者根据其估计肾小球滤过率（eGFR）处于 1 期至 3 期。一些血液学参数与 eGFR 呈正相关。需要改善 CKD 管理的多个方面，包括对慢性肾病儿童进行常规血液学检查。
