Dong Yiheng, Peng Naling, Dong Lini, Tan Shengyu, Zhang Xiangyu
Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Front Cardiovasc Med. 2022 Jul 28;9:937995. doi: 10.3389/fcvm.2022.937995. eCollection 2022.
Cardiac remodeling is a pathophysiological process activated by diverse cardiac stress, which impairs cardiac function and leads to adverse clinical outcome. This remodeling partly attributes to cardiac fibrosis, which is a result of differentiation of cardiac fibroblasts to myofibroblasts and the production of excessive extracellular matrix within the myocardium. Non-coding RNAs mainly include microRNAs and long non-coding RNAs. These non-coding RNAs have been proved to have a profound impact on biological behaviors of various cardiac cell types and play a pivotal role in the development of cardiac fibrosis. This review aims to summarize the role of microRNAs and long non-coding RNAs in cardiac fibrosis associated with pressure overload, ischemia, diabetes mellitus, aging, atrial fibrillation and heart transplantation, meanwhile shed light on the diagnostic and therapeutic potential of non-coding RNAs for cardiac fibrosis.
心脏重塑是一种由多种心脏应激激活的病理生理过程，它会损害心脏功能并导致不良临床结局。这种重塑部分归因于心脏纤维化，它是心脏成纤维细胞分化为肌成纤维细胞以及心肌内产生过多细胞外基质的结果。非编码RNA主要包括微小RNA和长链非编码RNA。这些非编码RNA已被证明对各种心脏细胞类型的生物学行为有深远影响，并在心脏纤维化的发展中起关键作用。本综述旨在总结微小RNA和长链非编码RNA在与压力超负荷、缺血、糖尿病、衰老、心房颤动和心脏移植相关的心脏纤维化中的作用，同时阐明非编码RNA在心脏纤维化诊断和治疗方面的潜力。
