Piccoli Maria-Teresa, Bär Christian, Thum Thomas
Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.
Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.
J Mol Cell Cardiol. 2016 Mar;92:75-81. doi: 10.1016/j.yjmcc.2015.12.023. Epub 2016 Jan 4.
Cardiac fibroblasts represent one of the most frequent cell type in the heart of rodents and humans and alterations of their phenotype have a great impact on cardiac function. Due to aging, ischemic injuries, valvular dysfunctions, hypertension and aortic stenosis, multiple signals trigger the accumulation of extracellular matrix in the cardiac interstitium and perivascular space, leading to structural and functional detrimental changes in the heart. Cardiac fibroblasts are the principal orchestrators of matrix formation and degradation and indirectly regulate cardiac hypertrophy and inflammation. Understanding the molecular bases of their action could provide tools for the treatment of cardiac remodeling. This review summarizes recent evidences on non-coding RNAs, including microRNAs and long non-coding RNAs that modulate the phenotype of cardiac fibroblasts and may serve in the future as targets for novel therapeutic strategies against cardiac fibrosis.
心脏成纤维细胞是啮齿动物和人类心脏中最常见的细胞类型之一，其表型改变对心脏功能有重大影响。由于衰老、缺血性损伤、瓣膜功能障碍、高血压和主动脉狭窄，多种信号触发细胞外基质在心脏间质和血管周围间隙的积累，导致心脏结构和功能的有害变化。心脏成纤维细胞是基质形成和降解的主要调节者，并间接调节心脏肥大和炎症。了解其作用的分子基础可为心脏重塑的治疗提供工具。本综述总结了关于非编码RNA的最新证据，包括调节心脏成纤维细胞表型的微小RNA和长链非编码RNA，它们未来可能成为抗心脏纤维化新治疗策略的靶点。
