Barger Steven W
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Immunometabolism (Cobham). 2022 Aug 5;4(3):e00003. doi: 10.1097/IN9.0000000000000003. eCollection 2022 Jul.
A shift in the energy-metabolism balance from oxidative phosphorylation to glycolysis is observed in several phenomena, from oncogenesis to differentiation. And this shift is not merely an indicator of the phenotypic change-an increase in glucose delivery often drives the adaption. At first blush, it seems that any route of entry should be equivalent, as long as sufficient quantities are supplied. However, an extensive study comparing the Th17 and Th1 subtypes of T cells now suggests that similar glucose transporters may not be interchangeable. Manipulation of individual transporters, or the downstream metabolites of their substrates, may afford dampening of autoimmunity potential with some degree of precision.
从肿瘤发生到细胞分化等多种现象中，都观察到能量代谢平衡从氧化磷酸化向糖酵解的转变。而且这种转变不仅仅是表型变化的一个指标——葡萄糖供应的增加往往会驱动这种适应性变化。乍一看，似乎只要供应足够的量，任何进入途径都应该是等效的。然而，一项比较T细胞的Th17和Th1亚型的广泛研究现在表明，相似的葡萄糖转运蛋白可能并非可互换的。对单个转运蛋白或其底物的下游代谢产物进行操控，可能会在一定程度上精准地抑制自身免疫潜能。
