Matz Alyssa J, Qu Lili, Karlinsey Keaton, Zhou Beiyan
Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT, USA.
Institute for Systems Genomics, University of Connecticut, Farmington, CT, USA.
Immunometabolism (Cobham). 2022 Aug 5;4(3):e00005. doi: 10.1097/IN9.0000000000000005. eCollection 2022 Jul.
Obesity is a prevalent health risk by inducing chronic, low-grade inflammation and insulin resistance, in part from adipose tissue inflammation perpetuated by activated B cells and other resident immune cells. However, regulatory mechanisms controlling B-cell actions in adipose tissue remain poorly understood, limiting therapeutic innovations. MicroRNAs are potent regulators of immune cell dynamics through fine-tuning a network of downstream genes in multiple signaling pathways. In particular, miR-150 is crucial to B-cell development and suppresses obesity-associated inflammation via regulating adipose tissue B-cell function. Herein, we review the effect of microRNAs on B-cell development, activation, and function and highlight miR-150-regulated B-cell actions during obesity which modulate systemic inflammation and insulin resistance. In this way, we hope to promote translational discoveries that mitigate obesity-induced health risks by targeting microRNA-regulated B-cell actions.
肥胖是一种普遍存在的健康风险，它会引发慢性低度炎症和胰岛素抵抗，部分原因是活化的B细胞和其他驻留免疫细胞使脂肪组织炎症持续存在。然而，控制脂肪组织中B细胞作用的调节机制仍知之甚少，这限制了治疗方法的创新。微小RNA通过微调多个信号通路中的下游基因网络，成为免疫细胞动态变化的有力调节因子。特别是，miR-150对B细胞发育至关重要，并通过调节脂肪组织B细胞功能来抑制肥胖相关炎症。在此，我们综述了微小RNA对B细胞发育、激活和功能的影响，并强调了肥胖期间miR-150调节的B细胞作用，这些作用调节全身炎症和胰岛素抵抗。通过这种方式，我们希望推动转化医学发现，通过靶向微小RNA调节的B细胞作用来减轻肥胖引起的健康风险。
