Huang Yukun, Liu Lu, Hao Zhenyu, Chen Lingna, Yang Qian, Xiong Xia, Deng Yongqiong
Department of Dermatology and STD, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
School of Nursing, Chengdu Medical College, Chengdu, China.
Front Microbiol. 2022 Jul 27;13:942027. doi: 10.3389/fmicb.2022.942027. eCollection 2022.
Acne vulgaris is a chronic inflammatory skin disease in which the influence of gut microbiota has been implicated but without clarification of mechanisms. Gut microbiota may exert such an influence via metabolites, particularly those of tryptophan. End metabolites of tryptophan activate receptors, including aryl hydrocarbon, G protein-coupled, and pregnane X receptors to stabilize the immune microenvironment and intestinal mucosal homeostasis. Any impact on the pathogenesis of acne vulgaris remains unclear. The current review collates recent advances concerning potential roles of tryptophan metabolism in mediating skin inflammation, follicular sebaceous gland function and intestinal permeability, all of which influence the pathogenesis of acne vulgaris. The aim was to improve understanding of the pathogenesis of acne vulgaris and to expose therapeutic opportunities.
寻常痤疮是一种慢性炎症性皮肤病，其中肠道微生物群的影响已被提及，但机制尚未明确。肠道微生物群可能通过代谢产物发挥这种影响，尤其是色氨酸的代谢产物。色氨酸的终末代谢产物激活包括芳烃受体、G蛋白偶联受体和孕烷X受体在内的受体，以稳定免疫微环境和肠道黏膜稳态。对寻常痤疮发病机制的任何影响仍不清楚。本综述整理了色氨酸代谢在介导皮肤炎症、毛囊皮脂腺功能和肠道通透性方面潜在作用的最新进展，所有这些都会影响寻常痤疮的发病机制。目的是增进对寻常痤疮发病机制的理解并揭示治疗机会。
