Dec Michał, Arasiewicz Hubert
Department of Dermatology and Vascular Anomalies, John Paul II Centre of Paediatrics, Sosnowiec, Poland.
Postepy Dermatol Alergol. 2024 Feb;41(1):9-19. doi: 10.5114/ada.2023.135617. Epub 2024 Feb 28.
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that has gained increasing attention in the field of dermatology due to its multifaceted role in skin health and disease. This review provides a comprehensive overview of the current state of knowledge regarding the AHR and its implications in dermatological conditions. The AHR is well known for its involvement in xenobiotic metabolism, particularly in response to polycyclic aromatic hydrocarbons and dioxins. However, recent research has unveiled its pivotal role in the skin immune response, barrier function, and homeostasis. The AHR signalling pathway is intricately linked to various dermatological disorders, including psoriasis, atopic dermatitis, acne and hidradenitis suppurativa. In this review, we delve into the molecular mechanisms through which AHR activation influences skin physiology and highlight how dysregulation can lead to pathological conditions. Moreover, we discuss the emerging therapeutic potential of AHR modulators in the treatment of skin diseases. In conclusion, the AHR is a pivotal player in dermatology, with a multifaceted role in skin physiology and pathology. Understanding the intricacies of AHR signalling in the skin offers promising avenues for the development of novel therapies and preventive strategies for various dermatological conditions. Further research is warranted to elucidate the full scope of AHR's contributions to dermatology and its potential as a therapeutic target.
芳基烃受体（AHR）是一种配体激活的转录因子，由于其在皮肤健康和疾病中的多方面作用，在皮肤病学领域受到越来越多的关注。本文综述了目前关于AHR的知识现状及其在皮肤病学中的意义。AHR以参与外源性物质代谢而闻名，尤其是对多环芳烃和二恶英的反应。然而，最近的研究揭示了它在皮肤免疫反应、屏障功能和内环境稳态中的关键作用。AHR信号通路与多种皮肤病密切相关，包括银屑病、特应性皮炎、痤疮和化脓性汗腺炎。在本文综述中，我们深入探讨了AHR激活影响皮肤生理的分子机制，并强调了失调如何导致病理状态。此外，我们还讨论了AHR调节剂在皮肤病治疗中的新兴治疗潜力。总之，AHR是皮肤病学中的关键角色，在皮肤生理和病理中具有多方面作用。了解皮肤中AHR信号的复杂性为开发各种皮肤病的新疗法和预防策略提供了有前景的途径。有必要进行进一步研究，以阐明AHR对皮肤病学的全面贡献及其作为治疗靶点的潜力。
