Huang Yukun, Liu Lu, Chen Linna, Zhou Lin, Xiong Xia, Deng Yongqiong
Department of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Ann Dermatol. 2021 Dec;33(6):531-540. doi: 10.5021/ad.2021.33.6.531. Epub 2021 Nov 4.
The gut microbial dysbiosis and gender differences in the pathogenesis of acne vulgaris have long been postulated respectively. However, there was no data about a gender-related discrepancy in gut microbiota and microbial metabolism in acne.
This study aimed at identifying the underlying gender-related difference in gut microbiota and metabolism in acne vulgaris.
Fecal samples were collected from 43 acne patients and 43 age and gender-matched controls. Gut microbiota was analyzed by sequencing the V3-V4 region of gene and microbial metabolites were quantitatively detected using gas chromatography time-of-flight mass spectrometry.
Compared with healthy controls, the men had a lower abundance of 18 microbes such as , , , , , , , , at genus level. However, the female patients only showed increased and declined and . Additionally, the disordered metabolism of fatty acids was identified in male patients, while the dysbiosis of amino acids metabolism in female ones.
The disorder of gut microbiota and metabolism in acne vulgaris was gender-specific, which supported the potential role of gender difference in the pathogenesis of this disease.
长期以来，人们分别推测肠道微生物群失调和性别差异在寻常痤疮发病机制中的作用。然而，尚无关于痤疮患者肠道微生物群和微生物代谢中性别相关差异的数据。
本研究旨在确定寻常痤疮患者肠道微生物群和代谢中潜在的性别相关差异。
收集43例痤疮患者和43例年龄及性别匹配的对照者的粪便样本。通过对基因的V3-V4区域进行测序分析肠道微生物群，并使用气相色谱飞行时间质谱法定量检测微生物代谢产物。
与健康对照相比，男性患者在属水平上有18种微生物（如 、 、 、 、 、 、 、 、 ）的丰度较低。然而，女性患者仅表现出 和 增加， 下降。此外，在男性患者中发现脂肪酸代谢紊乱，而女性患者则存在氨基酸代谢失调。
寻常痤疮患者肠道微生物群和代谢的紊乱具有性别特异性，这支持了性别差异在该疾病发病机制中的潜在作用。
