Yang Weina, Yang Xuemei, Zhang Su'e, Zhang Limei, Wang Wenze, Wang Li
Obstetrics Department, Shijiazhuang Obstetrics and Gynecology Hospital, Key Laboratory of Maternal and Fetal Medicine of Hebei Province, Shijiazhuang, Hebei, China.
Evid Based Complement Alternat Med. 2022 Aug 3;2022:2156424. doi: 10.1155/2022/2156424. eCollection 2022.
The study aimed to explore the correlation of serum chemokine (C-C motif) ligand 21 (CCL21) and heat shock protein 90 (Hsp90) with preeclampsia (PE).
Between June 2021 and June 2022, 50 pregnant women with PE were included in the PE group, and 50 healthy pregnant women were included in the control group. The serum levels of CCL21 and Hsp90 were compared between the two groups.
PE patients showed significantly higher levels of CCL21 and Hsp90 than healthy pregnant women ( < 0.05). Correlation analysis showed a positive correlation between CCL21 and Hsp90 levels ( > 0, ( < 0.05)). Binary logistic regression analysis suggested that high expression of CCL21 and Hsp90 were influencing factors for PE (OR >1, ( < 0.05)). The area under the receiver operating characteristic (AUC) curves of Hsp90 and CCL21 levels for predicting PE were 0.895 and 0.864, respectively, suggesting a good predictive value.
Serum CCL21 and Hsp90 show great potential as disease markers for PE prediction. Further trials are, however, required prior to clinical promotion.
本研究旨在探讨血清趋化因子（C-C基序）配体21（CCL21）和热休克蛋白90（Hsp90）与子痫前期（PE）的相关性。
2021年6月至2022年6月期间，将50例PE孕妇纳入PE组，50例健康孕妇纳入对照组。比较两组孕妇血清CCL21和Hsp90水平。
PE患者的CCL21和Hsp90水平显著高于健康孕妇（<0.05）。相关性分析显示CCL21和Hsp90水平呈正相关（>0，（<0.05））。二元逻辑回归分析表明，CCL21和Hsp90的高表达是PE的影响因素（OR>1，（<0.05））。Hsp90和CCL21水平预测PE的受试者工作特征（AUC）曲线下面积分别为0.895和0.864，提示具有良好的预测价值。
血清CCL21和Hsp90作为预测PE的疾病标志物具有很大潜力。然而，在临床推广之前还需要进一步试验。
