Sheng Guanyun, Yang Jing, Rong Peng, Yang Xueyi
Department of Orthopaedics, Liuzhou Traditional Chinese Medical Hospital, Guangxi University of Chinese Medicine, Liuzhou 545001, China.
Intensive Care Unit, Liuzhou Traditional Chinese Medical Hospital, Guangxi University of Chinese Medicine, Liuzhou 545001, China.
Evid Based Complement Alternat Med. 2022 Aug 4;2022:5467712. doi: 10.1155/2022/5467712. eCollection 2022.
To evaluate the effect of warm needle acupuncture plus Xitong Waixi lotion on the levels of IL-1, TNF-, and MMP-3 in patients with knee osteoarthritis.
Eighty patients with knee osteoarthritis admitted to our hospital from October 2019 to June 2021 were recruited and assigned via the random number table method at a ratio of 1 : 1 to receive either Xitong Waixi lotion (conventional group) or warm needle acupuncture plus Xitong Waixi lotion (combined group). Outcome measures included clinical efficacy, inflammatory cytokine level, Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, visual analogue scale (VAS) score, Hospital for Special Surgery (HSS) knee score, and adverse reactions.
Warm needle acupuncture plus Xitong Waixi lotion was associated with a significantly higher clinical efficacy versus Xitong Waixi lotion alone (=0.006). Patients in the combined group had significantly lower levels of interleukin (IL)-1, tumor necrosis factor- (TNF-), and matrix metalloproteinase-3 (MMP-3) than those in the conventional group (=0.020). Warm needle acupuncture plus Xitong Waixi lotion resulted in significantly lower WOMAC scores and VAS scores and higher HSS scores for the patients versus Xitong Waixi lotion (=0.012). The two groups had a similar incidence of adverse events (=0.068).
Warm needle acupuncture plus Xitong Waixi lotion effectively alleviates the inflammatory response and knee pain in patients with knee osteoarthritis, with significant clinical effects and a high safety profile.
评估温针联合西通外洗洗剂对膝骨关节炎患者白细胞介素-1（IL-1）、肿瘤坏死因子-α（TNF-α）和基质金属蛋白酶-3（MMP-3）水平的影响。
选取2019年10月至2021年6月我院收治的80例膝骨关节炎患者，采用随机数字表法按1∶1比例分为两组，分别给予西通外洗洗剂（常规组）或温针联合西通外洗洗剂（联合组）。观察指标包括临床疗效、炎症细胞因子水平、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分、视觉模拟评分法（VAS）评分、特殊外科医院（HSS）膝关节评分及不良反应。
温针联合西通外洗洗剂的临床疗效显著高于单用西通外洗洗剂（P = 0.006）。联合组患者的白细胞介素（IL）-1、肿瘤坏死因子-α（TNF-α）和基质金属蛋白酶-3（MMP-3）水平显著低于常规组（P = 0.020）。与西通外洗洗剂相比，温针联合西通外洗洗剂使患者的WOMAC评分和VAS评分显著降低，HSS评分显著升高（P = 0.012）。两组不良反应发生率相似（P = 0.068）。
温针联合西通外洗洗剂可有效减轻膝骨关节炎患者的炎症反应和膝关节疼痛，临床效果显著，安全性高。
