Yu Yi, Hu Jinhua, Xia Qun, Huang Juxia, Cheng Yangmei, Wu Fangling, Liu Yujing, Wang Jun, Zhang Qiong
Department of Ultrasound, Anqing First People's Hospital Affiliated to Anhui Medical University, Anqing, Anhui, China.
Department of Child Health, Shiyan Maternal and Child Health Hospital, Shiyan, Hubei, China.
Evid Based Complement Alternat Med. 2022 Aug 4;2022:2900378. doi: 10.1155/2022/2900378. eCollection 2022.
To investigate the ultrasound characteristics and clinical efficacy of coronary arteries before and after immune blocking therapy with gamma globulin in children with Kawasaki disease.
A total of 64 children with Kawasaki disease who were treated in our hospital from January 2018 to October 2021 were selected. All the children were given immune blocking therapy with gamma globulin on the basis of conventional treatment. The disappearance time of related symptoms and signs (fever, mucosal congestion, cervical lymphadenopathy, and swelling of the hands and feet) in children were counted. The white blood cell count (WBC), platelet count (PLT), C-reactive protein (CRP), and procalcitonin (PCT) levels of the children before and after treatment were compared, and the characteristics of coronary echocardiography before and after treatment were observed for analysis and discussion, to carefully observe whether the coronary artery involvement of the children was improved.
The inner diameter of the left and right coronary arteries significantly decreased ( < 0.05), and the levels of leukocytes, platelets, CRP, erythrocyte sedimentation rate, vascular endothelial growth factor (VEGF), and endostatin were significantly decreased compared with those before treatment, with a statistical difference ( < 0.05).
The effect of gamma globulin in the treatment of Kawasaki disease is remarkable, which can improve the blood indexes, VEGF, and endostatin levels in children, significantly reduce coronary dilatation, and reduce the incidence of coronary artery disease. Echocardiography is of high value in the examination of children with Kawasaki disease, which can accurately detect the size, location, and inner diameter of coronary artery lesions, and can effectively evaluate the treatment effect on children.
探讨川崎病患儿应用丙种球蛋白免疫阻断治疗前后冠状动脉的超声特征及临床疗效。
选取2018年1月至2021年10月在我院接受治疗的64例川崎病患儿。所有患儿在常规治疗基础上给予丙种球蛋白免疫阻断治疗。统计患儿相关症状和体征（发热、黏膜充血、颈部淋巴结肿大、手足肿胀）的消失时间。比较患儿治疗前后的白细胞计数（WBC）、血小板计数（PLT）、C反应蛋白（CRP）及降钙素原（PCT）水平，观察治疗前后冠状动脉超声心动图特征并进行分析讨论，仔细观察患儿冠状动脉受累情况是否改善。
与治疗前相比，左右冠状动脉内径显著减小（<0.05），白细胞、血小板、CRP、红细胞沉降率、血管内皮生长因子（VEGF）及内皮抑素水平显著降低，差异有统计学意义（<0.05）。
丙种球蛋白治疗川崎病效果显著，可改善患儿血液指标、VEGF及内皮抑素水平，显著减轻冠状动脉扩张，降低冠状动脉疾病发生率。超声心动图对川崎病患儿检查具有较高价值，可准确检测冠状动脉病变的大小、位置及内径，有效评估对患儿的治疗效果。
