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无创正压通气对慢性阻塞性肺疾病合并呼吸衰竭患者预后及血气水平的影响

Effect of Noninvasive Positive Pressure Ventilation on Prognosis and Blood Gas Level in COPD Patients Complicated with Respiratory Failure.

作者信息

Xiong Xiaoqing, Yuan Wensheng

机构信息

Department of Emergency, Jingzhou Hospital Affiliated to Yangtze University, Jingzhong 434020, Hubei, China.

出版信息

Evid Based Complement Alternat Med. 2022 Aug 5;2022:3089227. doi: 10.1155/2022/3089227. eCollection 2022.

DOI:10.1155/2022/3089227
PMID:35966741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9374560/
Abstract

Chronic obstructive pulmonary disease (COPD) is a respiratory disease caused by chronic bronchitis, which seriously threatens the life safety of patients. Noninvasive positive pressure ventilation (NIPPV) has great advantages in its treatment. Here, we explore the effect of NIPPV on prognosis and blood gas level in COPD patients complicated with respiratory failure (RF). A case control study was retrospectively analyzed, where 36 COPD patients with RF were regarded as the regular group to carry on the routine treatment, and 42 patients were assigned to the research group to carry out the routine treatment plus NIPPV. The monofactorial analysis showed that the overall response rate, forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and FEV1/FVC in the research group were higher than those in the regular group, while partial pressure of arterial carbondioxide (PaCO), posttreatment endotracheal intubation (EI), length of stay (LOS), tumor necrosis factor (TNF-), interleukin (IL)-6, IL-1, Acute Physiology and Chronic Health Evaluation (APACHE) II score, and modified Medical Research Council (mMRC) scores in the research group were lower than those in the regular group. These results indicated that NIPPV can improve the curative effect of emergency medicine patients with RF, improve BG level and PF, reduce inflammation, and facilitate patient's recovery.

摘要

慢性阻塞性肺疾病（COPD）是一种由慢性支气管炎引起的呼吸系统疾病，严重威胁患者的生命安全。无创正压通气（NIPPV）在其治疗中具有很大优势。在此，我们探讨NIPPV对合并呼吸衰竭（RF）的COPD患者预后和血气水平的影响。进行回顾性病例对照研究，将36例合并RF的COPD患者作为常规组进行常规治疗，42例患者分配至研究组进行常规治疗加NIPPV。单因素分析显示，研究组的总有效率、第1秒用力呼气容积（FEV1）、用力肺活量（FVC）和FEV1/FVC均高于常规组，而研究组的动脉血二氧化碳分压（PaCO）、治疗后气管插管（EI）、住院时间（LOS）、肿瘤坏死因子（TNF-）、白细胞介素（IL）-6、IL-1、急性生理与慢性健康状况评分系统（APACHE）II评分和改良英国医学研究委员会（mMRC）评分均低于常规组。这些结果表明，NIPPV可提高合并RF的急诊医学患者的疗效，改善血气水平和肺功能，减轻炎症反应，促进患者康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/bd671b090100/ECAM2022-3089227.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/44a3993d51a2/ECAM2022-3089227.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/ce734bf66a34/ECAM2022-3089227.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/ea8b3c799446/ECAM2022-3089227.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/0096eb8b9bdf/ECAM2022-3089227.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/bd671b090100/ECAM2022-3089227.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/44a3993d51a2/ECAM2022-3089227.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/ce734bf66a34/ECAM2022-3089227.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/ea8b3c799446/ECAM2022-3089227.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/0096eb8b9bdf/ECAM2022-3089227.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf0/9374560/bd671b090100/ECAM2022-3089227.005.jpg

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