Zhou Song-Jing, Tang Lin, Fu Yong-Jun, Yang Chang-Qing, Shi Jia
Department of Traditional Chinese Medicine, Hainan Provincial People's Hospital, Haikou 570311, China.
Evid Based Complement Alternat Med. 2022 Aug 4;2022:6992673. doi: 10.1155/2022/6992673. eCollection 2022.
To investigate the external application of traditional Chinese medicine in the prevention and treatment of nausea and vomiting caused by chemotherapy of non-small-cell lung cancer.
This is a prospective trial. A total of 114 patients with non-small-cell lung cancer who were hospitalized in our hospital from October 2020 to March 2022 were selected and randomly divided into the research group and the control group at the ratio of 1 : 1. The control group received chemotherapy + tropisetron 4 mg intravenous drip 30 minutes before chemotherapy./day × 3 days. The research group received chemotherapy + intravenous infusion of tropisetron 4 mg 30 minutes before chemotherapy, once a day for 3 days + external application of traditional Chinese medicine for 5 days. The therapeutic effects of the two groups of patients were compared.
After treatment, the serum creatinine, urea nitrogen, and endogenous creatinine in the research group were better than those in the control group ( = 15.943, 12.005, and 13.325; =0.001, 0.005, and 0.005). After treatment, ALT and TBIL in the research group were superior to those in the control group ( = 11.583, 10.012, and 9.426; =0.001, 0.002, and 0.001). After treatment, the physiological status, social/family status, emotional status, and family status of the research group were significantly better than those in the control group ( = 16.274, 5.379, 5.142, and 8.153; =0.005, 0.000, 0.002, and 0.001). After treatment, the ECOG score and KPS score (82.46 ± 4.61) of the research group were significantly different from those of the control group ( = 11.913 and 9.357; =0.035 and 0.001). The effective rate ( = 11.724; =0.000) of the research group was higher but the incidence of adverse reaction ( = 4.294; =0.001) was lower than that of the control group.
External application of traditional Chinese medicine can significantly reduce nausea and vomiting caused by chemotherapy of non-small-cell lung cancer and can improve the patient's body and quality of life, which is worthy of clinical research and promotion.
探讨中药外敷在防治非小细胞肺癌化疗所致恶心呕吐中的应用效果。
本研究为前瞻性试验。选取2020年10月至2022年3月在我院住院的114例非小细胞肺癌患者，按1∶1比例随机分为研究组和对照组。对照组在化疗前30分钟静脉滴注托烷司琼4mg，每日1次，共3天。研究组在化疗前30分钟静脉滴注托烷司琼4mg，每日1次，共3天，并加用中药外敷5天。比较两组患者的治疗效果。
治疗后，研究组血清肌酐、尿素氮及内生肌酐清除率均优于对照组（χ²=15.943、12.005、13.325，P=0.001、0.005、0.005）。治疗后，研究组谷丙转氨酶（ALT）及总胆红素（TBIL）水平优于对照组（χ²=11.583、10.012、9.426，P=0.001、0.002、0.001）。治疗后，研究组生理状况、社会/家庭状况、情感状况及家庭功能均显著优于对照组（χ²=16.274、5.379、5.142、8.153，P=0.005、0.000、0.002、0.001）。治疗后，研究组美国东部肿瘤协作组（ECOG）评分及卡氏功能状态评分（KPS评分）（82.46±4.61）与对照组比较差异有统计学意义（χ²=11.913、9.357，P=0.035、0.001）。研究组有效率（χ²=11.724，P=0.000）高于对照组，不良反应发生率（χ²=4.294，P=0.001）低于对照组。
中药外敷可显著减轻非小细胞肺癌化疗所致恶心呕吐，改善患者身体状况及生活质量，值得临床研究推广。
