Hu Jiaqi, Shen Yifeng, Zhang Ge, He Jie, Sun Mingxi, Zhang Haishan, Hua Baojin, Zheng Honggang
Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
School of Graduates, Beijing University of Chinese Medicine, Beijing.
Medicine (Baltimore). 2019 Sep;98(37):e17109. doi: 10.1097/MD.0000000000017109.
Patients suffering from chemotherapy-induced nausea and vomiting (CINV) might have negative adherence of treatment. Acupoint therapies, including acupuncture, acupressure, acupoints injection, massage, and moxibustion, are safe medical procedures with minimal side effects for CINV, but studies about overall safety and effectiveness of acupoint therapies have not been scientifically and methodically evaluated in recent years. Evaluating the overall safety and effectiveness of acupoint therapies in patients with CINV is the purpose of this review.
Relevant randomized controlled trials (RCTSs) are being searched in the following electronic databases: PubMed, Cochrane Library, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP database), Wanfang Data Knowledge Service Platform, and Chinese Biomedical Literature Database (CBM). We will also attempt to obtain the unpublished academic data by contacting the colleague, professor, or Institute of Traditional Chinese Medicine. The RCTs of the acupoint therapies for CINV patients will be searched in the databases from inception to July 2019. The primary outcomes are defined as severity, duration and frequency of nausea or vomiting, or both. The secondary outcomes are defined as any adverse events and quality of life. Performing the meta-analysis by using RevMan version 5 software. Mean difference (MD) or standardized mean difference (SMD) will express the continuous variables, while relative risk (RR) will express the categorical variables.
The results of this review will provide a high-quality synthesis to evaluate the effectiveness and safety of acupoint therapies for CINV.
This review will provide evidence to estimate whether acupoint therapies are effective interventions for CINV.
Evidence whether acupoint therapies are effective interventions for CINV will be provided by this systematic review. This knowledge will recommend better acupoint therapies and selections of acupoints which might be helpful in treating CINV. The findings of this systematic review will be disseminated via various forms of presentation and publication of the data in a journal or electronic databases.
CRD42019125538.
化疗引起的恶心和呕吐（CINV）患者可能存在治疗依从性差的情况。穴位疗法，包括针刺、指压、穴位注射、按摩和艾灸，是治疗CINV的安全医疗程序，副作用极小，但近年来关于穴位疗法的整体安全性和有效性的研究尚未得到科学、系统的评估。评估穴位疗法对CINV患者的整体安全性和有效性是本综述的目的。
在以下电子数据库中检索相关随机对照试验（RCT）：PubMed、Cochrane图书馆、科学网、EMBASE、中国知网（CNKI）、中文科技期刊数据库（维普数据库）、万方数据知识服务平台和中国生物医学文献数据库（CBM）。我们还将尝试通过联系同事、教授或中医机构获取未发表的学术数据。从数据库建库至2019年7月检索针对CINV患者的穴位疗法RCT。主要结局定义为恶心或呕吐的严重程度、持续时间和频率，或两者兼有。次要结局定义为任何不良事件和生活质量。使用RevMan 5软件进行荟萃分析。连续变量将用均值差（MD）或标准化均值差（SMD）表示，分类变量将用相对危险度（RR）表示。
本综述的结果将提供高质量的综合分析，以评估穴位疗法治疗CINV的有效性和安全性。
本综述将提供证据，以估计穴位疗法是否为治疗CINV的有效干预措施。
本系统评价将提供证据，证明穴位疗法是否为治疗CINV的有效干预措施。这些知识将推荐更好的穴位疗法和穴位选择，这可能有助于治疗CINV。本系统评价的结果将通过各种形式的报告以及在期刊或电子数据库中发表数据进行传播。
PROSPERO注册号：CRD42019125538。
