新发现的与肥胖症和2型糖尿病发病机制相关的脂肪因子。
New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes.
作者信息
Cheng Jia-Xue, Yu Ke
机构信息
Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, People's Republic of China.
出版信息
Diabetes Metab Syndr Obes. 2022 Aug 7;15:2381-2389. doi: 10.2147/DMSO.S376163. eCollection 2022.
Abstract
Obesity is defined as abnormal or excessive accumulation of adipose tissue, closely associated with the increased risk of various comorbidities, especially type 2 diabetes mellitus (T2DM). Adipose tissue is a complex structure responsible for not only fat storage but also releasing adipokines which may play roles in the pathogenesis and could be developed into biomarkers for diagnosis, treatment and prognosis of obesity-related metabolic diseases. This review aims to summarize several adipokines discovered recently that have promising functions in obesity and T2DM. Among them, the levels of FSTL1, WISP1 and Asprosin in subjects with obesity or diabetes are commonly higher than in normal controls, suggesting that they may be pathogenic. Inversely, SFRP5, Metrnl, NRG4 and FAM19A5 may serve as the protective factors.
摘要
肥胖被定义为脂肪组织异常或过度积累，这与各种合并症风险增加密切相关，尤其是2型糖尿病（T2DM）。脂肪组织是一种复杂的结构，不仅负责储存脂肪，还能释放脂肪因子，这些脂肪因子可能在发病机制中发挥作用，并有可能发展成为肥胖相关代谢疾病诊断、治疗和预后的生物标志物。本综述旨在总结最近发现的几种在肥胖和T2DM中具有潜在功能的脂肪因子。其中，肥胖或糖尿病患者体内的FSTL1、WISP1和Asprosin水平通常高于正常对照组，这表明它们可能具有致病性。相反，SFRP5、Metrnl、NRG4和FAM19A5可能是保护因子。
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