Gandhi Vivek Dipak, Shrestha Palikhe Nami, Vliagoftis Harissios
Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada.
Front Med (Lausanne). 2022 Jul 29;9:954990. doi: 10.3389/fmed.2022.954990. eCollection 2022.
PAR, a receptor activated by serine proteases, has primarily pro-inflammatory roles in the airways and may play a role in asthma pathogenesis. PAR exerts its effects in the lungs through activation of a variety of airway cells, but also activation of circulating immune cells. There is evidence that PAR expression increases in asthma and other inflammatory diseases, although the regulation of PAR expression is not fully understood. Here we review the available literature on the potential role of PAR in asthma pathogenesis and propose a model of PAR-mediated development of allergic sensitization. We also propose, based on our previous work, that PAR expression on peripheral blood monocyte subsets has the potential to serve as a biomarker of asthma severity and/or control.
蛋白酶激活受体（PAR）由丝氨酸蛋白酶激活，在气道中主要发挥促炎作用，可能在哮喘发病机制中起作用。PAR通过激活多种气道细胞在肺部发挥作用，但也能激活循环免疫细胞。有证据表明，PAR在哮喘和其他炎症性疾病中的表达增加，尽管对PAR表达的调节尚未完全了解。在此，我们综述了关于PAR在哮喘发病机制中潜在作用的现有文献，并提出了PAR介导的过敏性致敏发展模型。基于我们之前的工作，我们还提出，外周血单核细胞亚群上的PAR表达有可能作为哮喘严重程度和/或控制情况的生物标志物。
