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间充质干细胞在子痫前期中的病理及治疗作用

The pathological and therapeutic roles of mesenchymal stem cells in preeclampsia.

作者信息

Jin Sanshan, Wu Canrong, Chen Ming, Sun Dongyan, Zhang Hua

机构信息

Hubei University of Chinese Medicine, Wuhan, China.

Department of Traditional Chinese Medicine, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.

出版信息

Front Med (Lausanne). 2022 Jul 28;9:923334. doi: 10.3389/fmed.2022.923334. eCollection 2022.

Abstract

Mesenchymal stem cells (MSCs) have made progress in the treatment of ischemic and inflammatory diseases. Preeclampsia (PE) is characterized by placenta ischemic and inflammatory injury. Our paper summarized the new role of MSCs in PE pathology and its potency in PE therapy and analyzed its current limitations. Intravenously administered MSCs dominantly distributed in perinatal tissues. There may be additional advantages to using MSCs-based therapies for reproductive disorders. It will provide new ideas for future research in this field.

摘要

间充质干细胞(MSCs)在缺血性疾病和炎症性疾病的治疗方面取得了进展。子痫前期(PE)的特征是胎盘缺血和炎症损伤。我们的论文总结了间充质干细胞在子痫前期病理中的新作用及其在子痫前期治疗中的潜力,并分析了其当前的局限性。静脉注射的间充质干细胞主要分布在围产期组织中。使用基于间充质干细胞的疗法治疗生殖系统疾病可能还有其他优势。这将为该领域未来的研究提供新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14da/9370554/5d4ad43397f1/fmed-09-923334-g001.jpg

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