Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, United States.
Trends Immunol. 2009 Sep;30(9):430-8. doi: 10.1016/j.it.2009.06.002. Epub 2009 Aug 19.
Defects in T cell homeostatic mechanisms can result in T cell lymphopenia, defined as decreased numbers of lymphocytes. Lymphopenia results in homeostatic proliferation in order to maintain T cell homeostasis. It has been proposed that homeostatic proliferation can expand the pool of autoreactive T cells that promote autoimmunity, and indeed recent studies have further substantiated this observation in both animal models and humans. Conversely, homeostatic proliferation can promote tumor immunity by allowing tumor-specific T cells to accumulate. In this review, we discuss how the outcome of homeostatic proliferation can function both in a deleterious manner in autoimmunity and a beneficial way in tumor immunity. We also discuss the roles of various cytokines and T regulatory cells that control homeostatic proliferation.
T 细胞稳态机制的缺陷可导致 T 细胞淋巴细胞减少症，即淋巴细胞数量减少。淋巴细胞减少症导致为维持 T 细胞稳态而发生的稳态增殖。有人提出，稳态增殖可以扩增促进自身免疫的自身反应性 T 细胞池，实际上，最近的研究在动物模型和人类中进一步证实了这一观察结果。相反，通过允许肿瘤特异性 T 细胞积累，稳态增殖可促进肿瘤免疫。在这篇综述中，我们讨论了稳态增殖的结果如何既能在自身免疫中产生有害作用，又能在肿瘤免疫中产生有益作用。我们还讨论了控制稳态增殖的各种细胞因子和 T 调节细胞的作用。
