Zhang Weichunbai, Jiang Jing, He Yongqi, Li Xinyi, Yin Shuo, Chen Feng, Li Wenbin
Department of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
College of Nursing, University of South Florida, Tampa, FL, United States.
Front Nutr. 2022 Jul 29;9:935706. doi: 10.3389/fnut.2022.935706. eCollection 2022.
Brain tumor is one of the important causes of cancer mortality, and the prognosis is poor. Therefore, early prevention of brain tumors is the key to reducing mortality due to brain tumors.
This review aims to quantitatively evaluate the association between vitamins and brain tumors by meta-analysis.
We searched articles on PubMed, Cochrane Library, Web of Science, and Embase databases from inception to 19 December 2021. According to heterogeneity, the fixed-effects model or random-effects model was selected to obtain the relative risk of the merger. Based on the methods described by Greenland and Longnecker, we explored the dose-response relationship between vitamins and the risk of brain tumors. Subgroup analysis, sensitivity analysis, and publication bias were also used for the analysis.
The study reviewed 23 articles, including 1,347,426 controls and 6,449 brain tumor patients. This study included vitamin intake and circulating concentration. For intake, it mainly included vitamin A, vitamin B, vitamin C, vitamin E, β-carotene, and folate. For circulating concentrations, it mainly included vitamin E and vitamin D in the serum (25-hydroxyvitamin D and α-tocopherol). For vitamin intake, compared with the lowest intakes, the highest intakes of vitamin C (RR = 0.81, 95%CI:0.66-0.99, = 54.7%, = 0.007), β-carotene (RR = 0.78, 95%CI:0.66-0.93, = 0, = 0.460), and folate (RR = 0.66, 95%CI:0.55-0.80, = 0, = 0.661) significantly reduced the risk of brain tumors. For serum vitamins, compared with the lowest concentrations, the highest concentrations of serum α-tocopherol (RR = 0.61, 95%CI:0.44-0.86, = 0, = 0.656) significantly reduced the risk of brain tumors. The results of the dose-response relationship showed that increasing the intake of 100 μg folate per day reduced the risk of brain tumors by 7% ( = 0.534, RR = 0.93, 95%CI:0.90-0.96).
Our analysis suggests that the intake of vitamin C, β-carotene, and folate can reduce the risk of brain tumors, while high serum α-tocopherol concentration also has a protective effect on brain tumors. Therefore, vitamins may provide new ideas for the prevention of brain tumors.
PROSPERO, identifier CRD42022300683.
脑肿瘤是癌症死亡的重要原因之一，预后较差。因此，早期预防脑肿瘤是降低脑肿瘤死亡率的关键。
本综述旨在通过荟萃分析定量评估维生素与脑肿瘤之间的关联。
我们检索了从数据库建立至2021年12月19日在PubMed、Cochrane图书馆、科学网和Embase数据库上发表的文章。根据异质性，选择固定效应模型或随机效应模型来获得合并的相对风险。基于格陵兰和朗内克描述的方法，我们探讨了维生素与脑肿瘤风险之间的剂量反应关系。还进行了亚组分析、敏感性分析和发表偏倚分析。
该研究回顾了23篇文章，包括1347426名对照和6449名脑肿瘤患者。本研究包括维生素摄入量和循环浓度。对于摄入量，主要包括维生素A、维生素B、维生素C、维生素E、β-胡萝卜素和叶酸。对于循环浓度，主要包括血清中的维生素E和维生素D（25-羟基维生素D和α-生育酚）。对于维生素摄入量，与最低摄入量相比，维生素C（RR = 0.81，95%CI：0.66 - 0.99，I² = 54.7%，P = 0.007）、β-胡萝卜素（RR = 0.78，95%CI：0.66 - 0.93，I² = 0，P = 0.460）和叶酸（RR = 0.66，95%CI：0.55 - 0.80，I² = 0，P = 0.661）的最高摄入量显著降低了脑肿瘤风险。对于血清维生素，与最低浓度相比，血清α-生育酚的最高浓度（RR = 0.61，95%CI：0.44 - 0.86，I² = 0，P = 0.656）显著降低了脑肿瘤风险。剂量反应关系的结果表明，每天增加100μg叶酸的摄入量可使脑肿瘤风险降低7%（I² = 0.534，RR = 0.93，95%CI：0.90 - 0.96）。
我们的分析表明，维生素C、β-胡萝卜素和叶酸的摄入可降低脑肿瘤风险，而血清α-生育酚的高浓度对脑肿瘤也有保护作用。因此，维生素可能为脑肿瘤的预防提供新思路。
PROSPERO，标识符CRD42022300683。
