Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya J Med Sci. 2022 May;84(2):208-215. doi: 10.18999/nagjms.84.2.208.
The number of patients with ischemic cardiovascular diseases is significantly increasing as populations age. Therapeutic angiogenesis has been developed as a new treatment strategy for such patients. In recent years, the presence of mesenchymal stem cells in adipose tissues was reported, and regenerative medicine using these cells has attracted attention worldwide. In this review, we describe how the transplantation of adipose-derived regenerative cells enhances angiogenesis and tissue regeneration because of their multilineage potential and cytokine secretion. Then, the current status of therapeutic angiogenesis using adipose-derived regenerative cells in the field of cardiovascular medicine was also described. These cells present great advantages over bone marrow mononuclear cells, as these need easier, shorter, and less invasive preparations as well as less ethical concerns and immunological problems. The efficacy of adipose-derived regenerative cell transplantation in the treatment of various diseases was examined in several clinical trials with favorable results. Currently, a multicenter study of therapeutic angiogenesis using these cells is being conducted in patients with critical limb ischemia. In conclusion, we expect that this method will soon be established as a treatment for cardiovascular diseases that have been refractory to conventional treatments.
随着人口老龄化，缺血性心血管疾病患者的数量显著增加。治疗性血管生成已被开发为这类患者的一种新的治疗策略。近年来，人们发现脂肪组织中存在间充质干细胞，并且使用这些细胞的再生医学在全球范围内引起了关注。在这篇综述中，我们描述了脂肪来源的再生细胞如何通过其多能性和细胞因子分泌来增强血管生成和组织再生。然后，还描述了脂肪来源的再生细胞在心血管医学领域进行治疗性血管生成的现状。与骨髓单核细胞相比，这些细胞具有很大的优势，因为它们的制备更简单、更短、侵入性更小，并且较少涉及伦理问题和免疫问题。在几项临床试验中，脂肪来源的再生细胞移植在治疗各种疾病方面显示出良好的效果。目前，正在对这些细胞进行治疗严重肢体缺血患者的治疗性血管生成的多中心研究。总之，我们预计这种方法将很快成为治疗对传统治疗方法有抗性的心血管疾病的方法。
