Larsen Elizabeth A, Lack Amy C, Wassack Erica
Oklahoma State University Veterinary Medical Hospital, Stillwater, OK, United States.
Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University College of Veterinary Medicine, Mississippi State, MS, United States.
Front Vet Sci. 2022 Jul 29;9:783753. doi: 10.3389/fvets.2022.783753. eCollection 2022.
The use of poloxamer 407 gels have been reported in several studies to prolong the release of drugs at the injection site. Oral lesions unrelated to dental disease are rare but may result in ulceration and sequestration of bone. To date, there have been no reports on the use of penicillin G potassium poloxamer 407 gel and its effect on wound healing. The present case report describes the use of a penicillin G potassium poloxamer 407 gel for the treatment of a sublingual abscess involving the mandible in a 20 year old Arabian mare who initially presented with acute onset of dysphagia, hypersalivation, and a mass under the tongue. A presumptive diagnosis of lingual cellulitis was made, and a sublingual abscess ruptured on day 7 of hospitalization. In this case, poloxamer 407 gel was used to decrease wound contamination, protect the exposed mandible, and potentially prolong the release of penicillin G potassium into the wound.
多项研究报道了泊洛沙姆407凝胶可延长药物在注射部位的释放时间。与牙病无关的口腔病变较为罕见，但可能导致溃疡和骨隔离。迄今为止，尚无关于青霉素G钾泊洛沙姆407凝胶的使用及其对伤口愈合影响的报道。本病例报告描述了在一匹20岁的阿拉伯母马中使用青霉素G钾泊洛沙姆407凝胶治疗涉及下颌骨的舌下脓肿，该母马最初表现为急性吞咽困难、多涎和舌下肿物。初步诊断为舌蜂窝织炎，住院第7天舌下脓肿破裂。在本病例中，使用泊洛沙姆407凝胶以减少伤口污染，保护暴露的下颌骨，并可能延长青霉素G钾在伤口中的释放时间。
