Sreeja C, Priyadarshini A, Nachiammai N
Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India.
Department of Undergraduate Student, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2022 Apr-Jun;26(2):242-253. doi: 10.4103/jomfp.jomfp_373_21. Epub 2022 Jun 28.
Sarcoidosis is a granulomatous disorder of multiple organs, with lungs and lymphatic systems being the most frequently affected sites of the body. It was first reported in 1877 and has continued to engross both clinicians and scientists since that time. Because sarcoidosis being a diagnosis of exclusion, it demands the physician to rule out all the possible diagnosis. Most of the patients remain asymptomatic and this makes the disease remain unnoticed for a prolonged period. Later after years, the disease could be diagnosed after witnessing the patient being symptomatic or suffering from organ failures. It could affect middle aged people of any sexes, often its clinical features correlate with tuberculosis. On immunological and histopathological examination, it reveals noncaseating granuloma in simple terms. Glucocorticoids remain the standard drug now and then. Further research has to be done to know the exact pathogenesis, early detection and betterment in treatment plan of sarcoidosis. The current review article gives a brief knowledge about etiopathogenesis, Clinical features, upgraded diagnostic methods such as biomarkers detection and the organized treatment plan to treat sarcoidosis.
结节病是一种多器官的肉芽肿性疾病,肺和淋巴系统是身体最常受累的部位。它于1877年首次被报道,自那时起一直吸引着临床医生和科学家的关注。由于结节病是一种排除性诊断,它要求医生排除所有可能的诊断。大多数患者无症状,这使得该疾病在很长一段时间内未被发现。多年后,在患者出现症状或器官功能衰竭后才能诊断出该疾病。它可影响任何性别的中年人,其临床特征常与肺结核相关。在免疫和组织病理学检查中,简单来说,它显示为非干酪样肉芽肿。糖皮质激素仍然是目前常用的药物。必须进行进一步的研究以了解结节病的确切发病机制、早期检测以及改善治疗方案。当前的综述文章简要介绍了结节病的病因发病机制、临床特征、诸如生物标志物检测等先进的诊断方法以及有组织的治疗方案。