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皂苷对动物模型脑缺血的药理作用。

Pharmacological Effect of Saponins on Cerebral Ischemia in Animal Models.

机构信息

Department of Pharmacology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China.

Key Laboratory of Environment and Genes Related to Disease, Ministry of Education of the People's Republic of China, China.

出版信息

Biomed Res Int. 2022 Aug 4;2022:4281483. doi: 10.1155/2022/4281483. eCollection 2022.

DOI:10.1155/2022/4281483
PMID:35968235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9371884/
Abstract

saponins (PNS), bioactive compounds, are commonly used to treat ischemic heart and cerebral diseases in China and other Asian countries. Most previous studies of PNS have focused on the mechanisms underlying their treatment of ischemic cardiovascular diseases but not cerebral ischemic diseases. This study sought to explore the pharmacological mechanisms underlying the effectiveness of PNS in treating cerebral ischemic diseases. Different experimental cerebral ischemia models (including middle cerebral artery occlusion (MCAO) and the blockade of four arteries in rats, collagen-adrenaline-induced systemic intravascular thrombosis in mice, thrombosis of carotid artery-jugular vein blood flow in the bypass of rats, and hypoxia tolerance in mice) were used to investigate the mechanisms underlying the actions of PNS on cerebral ischemia. The results indicated that (1) PNS improved neurological function and reduced the cerebral ischemia infraction area in MCAO rats; (2) PNS improved motor coordination function in rats with complete cerebral ischemia (blockade of four arteries), decreased Ca levels, and ameliorated energy metabolism in the brains of ischemia rats; (3) PNS reduced thrombosis in common carotid artery-jugular vein blood flow in the bypass of rats; (4) PNS provided significant promise in antistroke hemiplegia and hypoxia tolerance in mice. In conclusion, PNS showed antagonistic effects on ischemic stroke, and pharmacological mechanisms are likely to be associated with the reduction of cerebral pathological damage, thrombolysis, antihypoxia, and improvement in the intracellular Ca overload and cerebral energy metabolism.

摘要

皂苷（PNS）是一种生物活性化合物，常用于治疗中国和其他亚洲国家的缺血性心脏和脑部疾病。大多数关于 PNS 的研究都集中在其治疗缺血性心血管疾病的机制上，而不是脑部缺血性疾病。本研究旨在探讨 PNS 治疗脑部缺血性疾病的药理学机制。不同的实验性脑缺血模型（包括大脑中动脉闭塞（MCAO）和大鼠四动脉阻断、胶原-肾上腺素诱导的小鼠系统性血管内血栓形成、大鼠颈动脉-颈静脉旁路血流血栓形成以及小鼠缺氧耐受）被用于研究 PNS 对脑缺血作用的机制。结果表明：（1）PNS 改善了 MCAO 大鼠的神经功能并减少了脑缺血损伤面积；（2）PNS 改善了完全性脑缺血（四动脉阻断）大鼠的运动协调功能，降低了 Ca 水平，并改善了缺血大鼠的脑能量代谢；（3）PNS 减少了大鼠颈动脉-颈静脉旁路血流的血栓形成；（4）PNS 在小鼠脑卒中偏瘫和缺氧耐受方面表现出显著的效果。综上所述，PNS 对缺血性中风具有拮抗作用，其药理学机制可能与减轻脑病理损伤、溶栓、抗缺氧以及改善细胞内 Ca 超载和脑能量代谢有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/3088d83bced1/BMRI2022-4281483.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/1e7f1d74cbe8/BMRI2022-4281483.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/063f1f11737d/BMRI2022-4281483.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/1c9062d8a125/BMRI2022-4281483.003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/3088d83bced1/BMRI2022-4281483.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/1e7f1d74cbe8/BMRI2022-4281483.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/063f1f11737d/BMRI2022-4281483.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/1c9062d8a125/BMRI2022-4281483.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/bb280bf73e9b/BMRI2022-4281483.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafc/9371884/3088d83bced1/BMRI2022-4281483.005.jpg

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