Achkar Michel, Jamal Omar, Chaaban Toufic
Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon.
Department of Internal Medicine, Lebanese American University Medical Center, Rizk Hospital, Beirut, Lebanon.
Ann Thorac Med. 2022 Jul-Sep;17(3):137-144. doi: 10.4103/atm.atm_103_22. Epub 2022 Jul 9.
Post-COVID lung impairment and diseases are major public health concern in the pandemic of COVID-19. Multiple etiological factors can lead to post-COVID respiratory symptoms, with post COVID fibrosis or diffuse parenchymal lung disease being the major concern. We searched PubMed database for English literature related to post-COVID lung disease and we summarized the existing evidence on radiological, physiological, and histopathological aspects of post-COVID lung diseases. We suggest a guidance on the evaluation of these patients and highlight management considerations including general care, pulmonary rehabilitation, and lung transplantation. We also explain gaps in knowledge and awaited ongoing research results, especially in the field of drug therapies including corticosteroids and antifibrotics.
新冠后肺部损伤和疾病是新冠疫情大流行期间的主要公共卫生问题。多种病因可导致新冠后呼吸道症状,其中新冠后肺纤维化或弥漫性实质性肺疾病是主要关注点。我们在PubMed数据库中检索了与新冠后肺部疾病相关的英文文献,并总结了关于新冠后肺部疾病放射学、生理学和组织病理学方面的现有证据。我们提出了对这些患者进行评估的指南,并强调了管理方面的考虑因素,包括一般护理、肺康复和肺移植。我们还解释了知识空白以及有待取得的研究结果,特别是在包括皮质类固醇和抗纤维化药物在内的药物治疗领域。