Department of Health Sciences, Kristiania University College, Oslo, Norway.
Faculty of Health and Social Sciences, Inland Norway University of Applied Science, Hamar, Norway.
Scand J Clin Lab Invest. 2022 Sep;82(5):404-409. doi: 10.1080/00365513.2022.2100820. Epub 2022 Aug 15.
Reference intervals are essential for correct interpretation of laboratory test results, supporting clinicians in distinguishing between healthy and sick individuals. The present study aims to establish pediatric reference intervals for hematological parameters based on a large population of healthy schoolchildren. Blood samples were obtained from 1351 children 6-12 years of age participating in the Health-Oriented Pedagogical Project (HOPP). Reference intervals for hematological parameters were estimated by the nonparametric method following the CLSI C28-A3 guidelines. Reference intervals were estimated as 2.5th and 97.5th percentiles with corresponding 90% confidence intervals. While hematocrit and MCV required age and sex partitioning, hemoglobin and erythrocytes were partitioned for age. The remaining parameters, MCH, MCHC, platelets and white blood cell counts did not require partitioning. While red blood cell parameters exhibited an increasing trend with age, there was a slight decrease in leukocytes, lymphocytes, basophils and platelets with age. The remaining parameters were stable across our age span.
参考区间对于正确解释实验室检测结果至关重要，有助于临床医生区分健康个体和患病个体。本研究旨在基于大量健康学龄儿童，建立儿童血液学参数的参考区间。从参加健康导向教学项目（HOPP）的 1351 名 6-12 岁儿童中采集血样。根据 CLSI C28-A3 指南，采用非参数法估计血液学参数的参考区间。参考区间估计为 2.5%和 97.5%百分位数，相应的 90%置信区间。虽然血细胞比容和 MCV 需要按年龄和性别分区，但血红蛋白和红细胞按年龄分区。其余参数，MCH、MCHC、血小板和白细胞计数不需要分区。虽然红细胞参数随年龄呈上升趋势，但白细胞、淋巴细胞、嗜碱性粒细胞和血小板随年龄略有下降。其余参数在我们的年龄范围内保持稳定。
