Division of Vascular Surgery, Department of Surgery, Ulsan University College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Department of Dermatology, College of Medicine, Hanyang University, Hanyang University Guri Hospital, Guri-si, Republic of Korea.
Angiology. 2023 Sep;74(8):721-727. doi: 10.1177/00033197221121010. Epub 2022 Aug 14.
This study aimed to evaluate the causal relationship between long-term outdoor air pollutants and incidence of peripheral arterial disease (PAD) using the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) database. We included 292,091 subjects from the general population who had previously not been diagnosed with PAD by the NHIS-NSC between 2008 and 2014. Hourly air pollutant data (particulate and gaseous) and climate data were collected. Correlation analysis of the collected data confirmed the relationship between air pollution and PAD incidence. For 1,836,965.4 person-years, incident cases of PAD were observed in 5243 subjects (285.4/100,000 person-years). In the Cox proportional hazard analysis, exposure to long-term average concentration of sulfur dioxide (SO) [hazard ratio (HR), 1.686; (95% confidence interval (CI), 1.108-2.565) for .01ppm] and nitrogen dioxide (NO) [HR, 1.200; (95% CI, 1.077-1.336) for .01 ppm] significantly increased the risk of PAD occurrence after the adjustment for several variables. This study demonstrated that SO and NO exposure are independent predictors of PAD.
本研究旨在利用韩国国民健康保险服务-国家样本队列（NHIS-NSC）数据库评估长期户外空气污染物与外周动脉疾病（PAD）发病之间的因果关系。我们纳入了 292091 名来自普通人群的受试者，他们在 2008 年至 2014 年间没有被 NHIS-NSC 诊断为 PAD。收集了每小时的空气污染物数据（颗粒物和气态）和气候数据。对收集的数据进行相关性分析证实了空气污染与 PAD 发病之间的关系。在 1836965.4 人年中，5243 名受试者（285.4/100000 人年）观察到 PAD 发病。在 Cox 比例风险分析中，暴露于长期平均浓度的二氧化硫（SO）[风险比（HR），1.686；（95%置信区间（CI），1.108-2.565）对于.01ppm]和二氧化氮（NO）[HR，1.200；（95% CI，1.077-1.336）对于.01ppm]在调整了几个变量后，显著增加了 PAD 发生的风险。本研究表明，SO 和 NO 的暴露是 PAD 的独立预测因子。
